Written by a leading researcher in immunology, ImmunoPharmaceuticals specifically focuses on immunologically active drugs recently tested for clinical activity or recently approved for medical use. Each chapter focuses on a single drug or class of drugs and discusses data from basic and preclinical research concerning mechanisms of action. Preclinical models are compared with clinical findings to allow the reader to evaluate the predictive value of those models. Featured drugs are being studied for therapy of cancer, arthritic disease, autoimmune disease, immunodeficiency disease, transplantation, and determination of sepsis. Overviews of the retinoids in cancer therapy and preclinical studies on flavonoids are featured.
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The objective behind this book is to highlight some of the most recently developed pharmaceuticals that hold promise as immunotherapeutics by examining the preclinical and pharmacological models used in their development, and to evaluate the predictive value of these tests by correlating them with clinical data, rather than simply concentrating on immune profiling using in vitro assays and immunotoxicological testing.
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