The Pharmacology and Toxicology of Proteins: Symposium Proceedings (UCLA Symposia on Molecular and Cellular Biology, New Series) - Hardcover

Hardcover

ISBN 10: 0845126644 ISBN 13: 9780845126646

Publisher: Alan R. Liss, 1987

Synopsis

A summary of the problems and features of the use of proteins and peptides as drugs is provided by this volume. The use of new molecular, biological and genetic engineering techniques to improve protein structure and function are thoroughly explored. Examples of protein and peptide drugs are examined, illustrating the current advances in defining the targets of these proteins and the genetic engineering techniques used to improve their biological and pharmacological properties. The unique pharmacological properties of proteins are presented, with examples of receptor binding and transport. The following sections examine the pharmacokinetics of chemically modified proteins and peptides, giving information on controlled release dosage forms. Immune responses and development of tolerance to these foreign materials, and the toxicology of proteins, are also reviewed. Other topics examined include: the clinical pharmacology of monoclonal antibodies, interleukin-2, interferons, atriopeptin, and protease inhibitors; the combination of protein therapy with other treatments and the potential of exogenously administered enzymes to treat genetic disorders.

About this edition

• Publisher: Alan R. Liss
• Publication date: 1987
• ISBN 10: 0845126644
• ISBN 13: 9780845126646
• Binding: Hardcover
• Number of pages: 400
• Editor: Holcenberg John S., Winkelhake Jeffrey J.