Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics - Softcover

Pecorino, Lauren

3.96

69 ratings by Goodreads

9780199211487: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics

Softcover

ISBN 10: 0199211485 ISBN 13: 9780199211487

Publisher: OUP Oxford, 2008

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Many of the cells in our body undergo tightly regulated replication to enable growth to occur, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail. The second edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics gives a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: � Figures from the book available to download, to facilitate lecture preparation � A testbank of multiple-choice questions, with feedback linked to the book, for use in formative or summative assessment For students: � A web link library, giving easy access to relevant online resources � Hyperlinks to primary literature articles cited in the text

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Review:

I found this book very very helpful in understanding this otherwise very difficult subject. I think this is the only book which has been written for the learners. The writing style, illustrations and the unique features like 'pause and think' are unprecendented and very helpful. Lauren Pecorino must be a very good teacher. (Dr Waqqar Ali, Registrar Radiation Oncology, Cork University Hospital)

Review of current edition: The textbook is clearly written and the author does a great job of introducing some of the more fundamental concepts. The book is organized well and the topics flow smoothly and logically. The book also nicely pulls in current therapeutic approaches with the molecular lesions that are responsible for the generation of cancer. (Professor Deobrah Vestal, Department of Biological Sciences, University of Toledo, USA.)

Review from previous edition The author's infectious enthusiasm as a teacher comes across on every page of this beautifully illustrated book. To guide her readers through this increasingly complex field, she introduces some novel features, including "Special interest" boxes, sections labelled, "Pause to think," well-designed chapter highlights and aids to "Memory refreshment." Given the speed of development of this field, the book is remarkably up to date. (Sir David Weatherall, Emeritus Regius Professor of Medicine, Oxford University in THES Textbook Guide - February 2006)

About the Author:

Lauren Pecorino is Senior Lecturer and Biochemistry Program Leader at the University of Greenwich, UK.

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