The Organic Chemistry of Enzyme-catalyzed Reactions - Hardcover

Silverman, Richard B.

Hardcover

ISBN 10: 0126437459 ISBN 13: 9780126437454

Publisher: Academic Press Inc, 1999

Synopsis

Written for advanced undergraduate and graduate students as well as professionals in organic and medicinal chemistry and biochemistry, this unique text illuminates the "black box" of enzyme-catalyzed reactions by showing how enzymes are simply highly efficient organic chemists. Enzyme-catalyzed reactions are essential for the design of enzyme inhibitors in the pharmaceutical and agricultural industries, and of growing importance for process development in the chemical and biotechnology industries. Following a general introduction to the role of enzymes as catalysts, each chapter describes the organic reaction mechanisms that are used by enzymes to catalyze a particular family of organic transformations. The compilation includes a vast number of drawings to illustrate structures and mechanisms, and focuses on one or two examples of enzymes that catalyze the particular chemistry for that transformation. The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather the general mechanisms used by enzymes. Extensive references refer to the many experiments that have helped to elucidate enzyme mechanisms. Chemical model studies as an aid in mechanistic studies are also discussed, as are the design of haptens and the generation of catalytic antibodies ("designer enzymes"). Problem sets and solutions are provided to check the reader's understanding of the principles described.

About this title

Review:

"Whether you are teaching, learning, or trying to inhibit an enzyme, you will find this book invaluable."--JOURNAL OF MEDICINAL CHEMISTRY, 2000, Vol. 43, No 13"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ...it may easily serve as the foundation for an advanced course on contemporary topics of substrate recognition, activation, and catalytic turnover. His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated for publishing yet another book of high quality and significance. This newest contribution to enzymology should quickly become the standard for mechanistic studies. Ample figures and schemes enliven each section, and all aspects fo teh text have been composed with great precision. Silverman simultaneously elucidates both the experimental approaches and results that constitute much of enzymology."--Steven Rokita, University of Maryland; JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, June 14, 2000, Vol. 122, No. 33."Successfully highlights some of the most sophisticated advances of the past decade while still covering the basic tenets of enzymology. Silverman should be congratulated for publishing yet another book of high quality and significance. The newest contribution to enzymology should quicly become the standard for mechanistic studies. Ample figures and schemes enliven each section, and all aspects of the text have beeen composed with great precision. Silverman simultaneously elucidates both the experimental approaches and the results that constitutemuch of enzymology."--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, June 14, 2000, Vol. 122, No. 33.

About the Author:

Professor Richard B. Silverman received his B.S. degree in chemistry from The Pennsylvania State University in 1968 and his Ph.D. degree in organic chemistry from Harvard University in 1974 (with time off for a two-year military obligation from 1969-1971). After two years as a NIH postdoctoral fellow in the laboratory of the late Professor Robert Abeles in the Graduate Department of Biochemistry at Brandeis University, he joined the chemistry faculty at Northwestern University. In 1986, he became Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology. In 2001, he became the Charles Deering McCormick Professor of Teaching Excellence for three years, and since 2004 he has been the John Evans Professor of Chemistry. His research can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents acting on enzymes and receptors.

His awards include DuPont Young Faculty Fellow (1976), Alfred P. Sloan Research Fellow (1981-1985), NIH Research Career Development Award (1982-1987), Fellow of the American Institute of Chemists (1985), Fellow of the American Association for the Advancement of Science (1990), Arthur C. Cope Senior Scholar Award of the American Chemical Society (2003), Alumni Fellow Award from Pennsylvania State University (2008), Medicinal Chemistry Hall of Fame of the American Chemical Society (2009), the Perkin Medal from the Society of Chemical Industry (2009), the Hall of Fame of Central High School of Philadelphia (2011), the E.B. Hershberg Award for Important Discoveries in Medicinally Active Substances from the American Chemical Society (2011), Fellow of the American Chemical Society (2011), Sato Memorial International Award of the Pharmaceutical Society of Japan (2012), Roland T. Lakey Award of Wayne State University (2013), BMS-Edward E. Smissman Award of the American Chemical Society (2013), the Centenary Prize of the Royal Society of Chemistry (2013), and the Excellence in Medicinal Chemistry Prize of the Israel Chemical Society (2014).

Professor Silverman has published over 320 research and review articles, holds 49 domestic and foreign patents, and has written four books (The Organic Chemistry of Drug Design and Drug Action is translated into German and Chinese). He is the inventor of LyricaTM, a drug marketed by Pfizer for epilepsy, neuropathic pain, fibromyalgia, and spinal cord injury pain; currently, he has another CNS drug in clinical trials.

About this edition

• Publisher: Academic Press Inc
• Publication date: 1999
• ISBN 10: 0126437459
• ISBN 13: 9780126437454
• Binding: Hardcover
• Number of pages: 534