Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition - Hardcover

Roger N. Rosenberg

Hardcover

ISBN 10: 0124105297 ISBN 13: 9780124105294

Publisher: Academic Press, 2014

Synopsis

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format.

Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases.

• Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease
• Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain
• Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

About this title

Review:

A complete introduction and reference on the neurogenetics of neurological and psychiatric disease

About the Author:

Roger N. Rosenberg, MD holds the Abe (Brunky), Morris and William Zale Distinguished Chair and Professor of Neurology, University of Texas Southwestern Medical Center at Dallas. He served as Chair of the Department of Neurology from 1973- 1991. He is the founding Director of the NIH funded Alzheimer’s Disease Center at UT Southwestern and it has been funded through five consecutive competitive funding cycles since 1988 and will be funded through 2016 representing 27 years of continuous NIH Center funding. He is certified by the American Board of Psychiatry and Neurology. He served as Chief Resident in Neurology to H. Houston Merritt, MD, Neurological Institute, Columbia University Medical Center, New York, 1967-1968. He was a Post-Doctoral Research Fellow for Marshall Nirenberg, PhD, Laboratory of Biochemical Genetics, National Institutes of Health, 1968-1970.

Dr. Rosenberg has received important honors and awards including the prestigious UT Chancellor’s Discovery Lecture, invited by Chancellor Francisco Cigarroa for the Chancellor’s Council Meeting and Symposium, the University of Texas System, 2013. The Discovery Lecture was: “DNA Aß42 Vaccination as Therapy for Alzheimer’s Disease . He was awarded the World Federation of Neurology, 1st Science Medal for Scientific Achievements in Neurology and Neuroscience, presented at the World Congress of Neurology in Bangkok, Thailand in 2009.

He is an Honorary Member (Elected) of the American Neurological Association, 2006 and the American Academy of Neurology 1997.

He received the Nancy R. McCune Research Award of the Alzheimer’s Association (AWARE) (2005).

He was the Robert Wartenberg Lecturer of the American Academy of Neurology, 2000, and his lecture was “The Molecular and Genetic Basis of Alzheimer’s Disease .

He is an elected Honorary Member, Spanish Neurological Society, 1994. He was awarded the 1st Distinguished Neurology Alumnus Award of the Neurological Institute; Columbia University Medical Center; 1994.

He has been the Editor in Chief, JAMA Neurology (1997- present) and a member of the Editorial Board of JAMA (1997-present).

He was elected a Fellow, American Association for the Advancement of Science, February 1991

He was elected President of the American Academy of Neurology (1991-1993) and

1st Vice President of the American Neurological Association (1988-89). He received the Northwestern University Medical School Alumni Association Merit Award (1986).

In 2006, he published for the first time that a DNA A ß42 vaccine administered with the gene gun method into the skin of Alzheimer disease model mice can reduce Aß42 peptide levels in the brain by 50% with anti-A ß42 antibody of the IgG1/Th2 type which is known to be anti-inflammatory. He received in 2009 a US Patent as Inventor of “Amyloid ß Gene Vaccines . This DNA vaccine has the potential to be a safe and effective therapy to prevent Alzheimer disease.

He described Machado-Joseph disease (MJD), an autosomal dominant ataxia, with William Nyhan, M.D. Ph.D, in 1976, for the first time. MJD is now the most common autosomal domiant spinocerebellar ataxia world-wide.

Dr. Rosenberg has published over 270 original scientific papers, chapters, reviews and editorials. He is the founding editor and senior editor since 1993 for all five editions of “The Molecular and Genetic Basis of Neurological and Psychiatric Diseases .

About this edition

• Publisher: Academic Press
• Publication date: 2014
• ISBN 10: 0124105297
• ISBN 13: 9780124105294
• Binding: Hardcover
• Edition number: 5
• Number of pages: 1464
• Editor: Roger N. Rosenberg, Juan M. Pascual