Natural Hosts of SIV: Implication in AIDS - Hardcover

Hardcover

ISBN 10: 0124047343 ISBN 13: 9780124047341

Publisher: Elsevier, 2014

Synopsis

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

• Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models
• Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV
• Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

About this title

Review:

Discusses the most recent advances on the mechanisms of protection from disease progression in natural SIV hosts, emphasizing how they differ from pathogenic HIV/SIV infections of humans and rhesus macaques.

From the Back Cover:

Natural Hosts of SIV: Implications in AIDS delivers a comprehensive review of the possible mechanism(s) by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free when other hosts exhibit disease and death, ultimately aiming to shed light on arenas for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

Aiming to elucidate this captivating occurrence, Natural Hosts of SIV delivers a composite view of the virological, immunological, genetic and molecular aspects of virus-host relationships of SIV infection of natural hosts. Without an effective sterilizing vaccine again HIV-1, defining the methodologies by which an HIV-1 infected individual remain infected and disease-free, like the African nonhuman natural hosts of the simian immunodeficiency viruses (SIV), is particularly compelling. Understanding the potential mechanisms by which these natural hosts avoid disease development despite high viral loads could provide a road map for the formulation of an alternate vaccine strategy against HIV-1. This work makes important in-roads to enhance an understanding of whether the mechanisms at work in this scenario can be successfully exploited for therapeutic application in HIV-1 infected humans.

Key Features

· Summarizes the research conducted in this field for the past 30 years and describes the latest developments in AIDS research using nonhuman primate animal models · Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV · Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

About this edition

• Publisher: Elsevier
• Publication date: 2014
• ISBN 10: 0124047343
• ISBN 13: 9780124047341
• Binding: Hardcover
• Edition number: 1
• Number of pages: 400
• Editor: Ansari Aftab A., Silvestri Guido