Post-Genomic Cardiology

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9780124045996: Post-Genomic Cardiology

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the "epigenome," comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist Jose Marin-Garcia, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. * Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches* Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome* Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

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"This Second edition of Post-Genomic Cardiology (PCG) deals with what promises to be the cardiology of the future. As the role of genetic screening in cardiology is strengthened, and as research on the multiple signaling pathways involved in cardiac organogenesis and pathology progresses, this 2nd edition of PCG further attempts to integrate known facts with what is still developing and with what is slowly becoming known. New areas of interest to cardiologists and researchers include systems biology, the constructive cycle of computational model building, and experimental verification. These are capable of providing the input necessary for exciting new discoveries, including the management of diseases in a "personalized way. The book is fascinating because it introduces a field that no one with a minimum amount of scientific interest will be able to avoid in the very near future. Extensively referenced, and thoroughly researched, this book presents well-written and organized chapters, each with a summary of the important points discussed, followed by exhaustive bibliographies. A detailed glossary clearly defines the many acronyms used throughout the book. Unquestionably, this volume will be of great interest and use to clinical and research cardiologists, pharmacologists and genetics investigators; and to students of basic sciences. Dr. Marin-Garcia - author and editor of this 2nd edition of PGC has done an outstanding job of completing this challenging task." - Dr. Daniel Shindler "This is a great book. It shows the XXII century medicine. Congratulations. Dr. A. Bayes de Luna Emeritus Professor Autonomic University. Barcelona --Dr. A. Bayes de Luna

About the Author:

Dr.Jose Mar n-Garc a, highly respected cardiologist, is the current Director of Molecular Cardiology and Neuromuscular Institute in Highland Park, NJ. He has 189 listed publications and an H-index of 30. He has written and edited Mitochondria and the heart (2005), Aging and the Heart (2008), Signaling in the Heart (2008). Heart Failure (2010), Post-Genomic Cardiology (2007), and Mitochondria and Their Role in Cardiovascular Disease (2012).

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Book Description Book Condition: New. Publisher/Verlag: Academic Press | In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the "epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach.This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA.Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approachesAnalyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndromePresents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs | DedicationPrefaceSection I: Post-Genomic CardiologyChapter 1. Introduction to the Molecular Biology of the CellNucleic Acids, Genes, Chromatin, and ChromosomesDNA Transacting Processes: Replication, Transcription, and RepairGenetic Variability Associated with Human DiseasesCell CycleReferences Chapter 2. Methodologies in the Era of Cardiovascular "OmicsIntroductionGenomics Approaches: NGS and GWASTranscriptomicsProteomics and InteractomicsMetabolomicsCardiac ImagingTranslational BioinformaticsConclusionsSummaryReferences Chapter 3. Post-Genomics Cardiovascular Signaling PathwaysIntroductionCardiac Signaling in Physiological GrowthCa 2+ -Mediated SignalingSignaling at the Plasma MembraneSignaling at the MitochondriaCell-Cycle signaling, cell proliferation, and apoptosisStress, Survival, and Metabolic SignalingSignaling in Cardiac Development and AgingConclusionSummaryReferences Section II: Pediatric Cardiology in the Post-Genomic EraChapter 4. Molecular Determinants of Cardiac DevelopmentIntroductionOverview of Cardiac MorphogenesisMicroRNAs in Cardiovascular DevelopmentConclusionsSummaryReferences Chapter 5. Molecular Determinants of Congenital Heart DiseaseIntroductionEtiology of CHD: Interplay of Genetic and Environmental FactorsMolecular Mechanisms of CHDSyndromic CHDs Caused by Point MutationsNonsyndromic CHDs Caused by Point MutationsNon-Syndromic CHD Caused by Impaired Signaling PathwaysNonsyndromic CHD Caused by Point Mutations in Transcription FactorsNonsyndromic CHDs Caused by Point Mutations in Structural ProteinsNoncoding RNAs and CHDConclusionsSummaryReferences Section III: Post-Genomic Assessment of Coronary Artery Disease, Angiogenesis, and HypertensionChapter 6. Molecular Determinants of AtherosclerosisOverview of AtherogenesisLipoproteinsEndothelial DysfunctionRho Kinases and Statins in AtherosclerosisTumor Necrosis Factor (TNF) in AtherogenesisMonocytes and MacrophagesAntiinflammatory FactorsConclusionSummaryReferences Chapter 7. Molecular Genetics of Coronary Artery Disease and Myocardial InfarctionIntroductionAnimal StudiesLinkage and Genome-Wide Association Studies in Myocardial IschemiaCandidate Gene Identification ApproachGenes and Inflammatory Signaling Pathways Involved in CAD/MIOther Signaling Pathways in CAD/MIAdditional Gene LOCI Associated with MISex Hormone and MIGene Profiling in Myocardial Ischemia/InfarctGenetics and Ethnic Differences in Coronary Artery DiseaseBeyond GWASMicroRNAs Markers in CAD/MIConclusionsSummaryReferences Chapter 8. Cellular and Molecular Aspects of CardioprotectionIntrod. Bookseller Inventory # K9780124045996

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Book Description Elsevier Science Publishing Co Inc, United States, 2014. Hardback. Book Condition: New. 2nd Revised edition. 279 x 221 mm. Language: English . Brand New Book. In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist Jos Mar n-Garc a, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. * Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches* Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome* Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs. Bookseller Inventory # AA59780124045996

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Book Description Elsevier Science Publishing Co Inc, United States, 2014. Hardback. Book Condition: New. 2nd Revised edition. 279 x 221 mm. Language: English . Brand New Book. In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist Jos Mar n-Garc a, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. * Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches* Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome* Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs. Bookseller Inventory # AA59780124045996

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