Recent Advances in Electron Cryomicroscopy: Pt. A: 82 (Advances in Protein Chemistry & Structural Biology): Volume 81 (Advances in Protein Chemistry and Structural Biology, Volume 81) - Hardcover

Hardcover

ISBN 10: 0123813573 ISBN 13: 9780123813572

Publisher: Academic Press, 2010

Synopsis

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

• Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
• Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

About this title

Review

This volume presents step-by-step techniques for researchers that will predict the structure and potential function of proteins by identifying its coding sequence

About this edition

• Publisher: Academic Press
• Publication date: 2010
• ISBN 10: 0123813573
• ISBN 13: 9780123813572
• Binding: Hardcover
• Number of pages: 144
• Editor: Venkataram Vidya, Ludtke Steve