Johansen-Berg Diffusion MRI

ISBN 13: 9780123747099

Diffusion MRI

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9780123747099: Diffusion MRI

Diffusion imaging is a non-invasive MR technique that is now being used in novel ways to study aspects of white matter anatomy that could never before be investigated in the living brain. The technique therefore has enormous potential for addressing novel research questions in both basic and clinical neuroscience.
This book aims to cover the field of diffusion imaging from the fundamental theory to its most cutting-edge applications. It contains sufficient detail to be a reference book for medical physicists, but will also cover fundamental aspects of experimental design and example applications that will be of interest to clinical and basic neuroscientists. Importantly, the book presents diffusion imaging in the context of well-established, classical experimental techniques, so that readers will be able to assess the scope and limitations of the new imaging technology with respect to techniques available previously.
Each section includes chapters on methodology (with the more advanced, mathematical material included in appendices for the interested reader), validation of the imaging technology, and application of diffusion imaging to the study of variation and development of normal brain anatomy, and disruption to the white matter in neurological disease or psychiatric disorder.
The aim of the book is to become an essential reference text for scientists designing or interpreting diffusion MR experiments.

Key Features

- The first comprehensive reference on a powerful technique in Brain Imaging
- Contributions from the key scientists in the field, including pioneers of the field Peter BAsser (NIH), Susumu Mori (Johns Hopkins University), and others
- Describes the physical foundations, methods for quantitative analysis, and how the technique is applied to the cutting edge analysis of connections in the brain
- Full color throughout, carefully edited for clarity in style

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Review:

"A thorough and exciting review of the diffusion MRI techniques that are going to rewrite our knowledge of the long tract anatomy of the human brain. Extremely well written and illustrated." - Michael S. Gazzaniga, Director, Sage Center for the Study of Mind, University of California, Santa Barbara, USA "25 years after its debut, diffusion MRI today provides us with beautiful, marvelous images of connecting wires within the human brain, and this is achieved just by placing healthy subjects or patients in the middle of a strong magnet. How is this miracle possible? What could we expect from the knowledge of the brain connectome? This beautifully illustrated book addresses these questions with great clarity. The book is highly recommendable to all those who are interested in the links between brain structure and function." - Denis Le Bihan, Member of the Institut de France, Academy of Sciences; Director, NeuroSpin; CEA-Saclay Center, Gif-sur-Yvette, France "Unbelievable as it may seem, we know almost nothing about the real connectivity of the human cerebral cortex. What we think we know is mostly inferred from results obtained in the monkey. This book provides an exciting exploration of diffusion tensor imaging, a method that can start to close this gap. The editors, who are themselves pioneers in this field, have assembled authoritative chapters on the promises that lie ahead and the challenges that will be encountered." - Marsel Mesulam, Ruth and Evelyn Dunbar Professor of Neurology, Psychiatry and Psychology; Director, The Cognitive Neurology and Alzheimer's Disease Center (CNADC), Feinberg School of Medicine, Northwestern University, Chicago, USA "Diffusion MRI has tremendous potential for elucidating brain structure and circuitry in health and disease, but the approach is fraught with methodological and interpretational challenges. This excellent and authoritative book edited by Johansen-Berg and Behrens is an invaluable resource for everyone using diffusion MRI or wanting to learn more about it." - David C. Van Essen, Edison Professor and Department Head, Anatomy and Neurobiology Department, Washington University School of Medicine, St. Louis, USA

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