The immunoglobin gene complex is responsible for generating an extraordinary wide range of antbodies, each possessing a unique antigen specificity. The Second Edition of Immunogobulin Genes brings the reader up-to-date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement, and expression of these and related genes. Since the publication of the First Edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammmalian and lower vertebrate systems. New chapters include "Somatic Mutation and B-Cell Maturation," "Antigen Receptors," and "B Lymphocyte Tolerance in the Mouse." Features: * Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues * Contains invaluable information for clinicians and research scientists with an interest in the immune response * For the Immunologist * Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them * For the Molecular Biologist * Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes.
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"Compelling reading...It is probably the best available account of this fascinating and important subject." -- CELL BIOCHEMISTRY AND FUNCTION
"Will be of great use to those just beginning a career in immunology or those in other fields wishing to familiarize themselves with the subject" -- TRENDS IN BIOCHEMICAL SCIENCES
From the Reviews of the First Edition " An enormous amount of material condensed in [one] book. It is useful for advanced students or postdocs who want to gain access to the field, as well as researchers in the field who wish to check up on a particular aspect and/or find a quick way into the corresponding literature." -- IMMUNOLOGY TODAY
Edited by Dr. Tasuku Honjo and Dr. Frederick W. Alt
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Book Description Academic Press, 1995. Hardcover. Book Condition: New. Bookseller Inventory # P110120536404
Book Description Academic Press, 1995. Hardcover. Book Condition: New. Bookseller Inventory # SONG0120536404
Book Description Academic Press, 1995. Hardcover. Book Condition: New. 2. Bookseller Inventory # DADAX0120536404