Psychoneuroimmunology is the study of interactions between the brain and the immune system. This book provides a clearly written, extensively referenced summary of the behavioral, neural and endocrine regulation of immune responses and of the effects of immune system activity on neural and endocrine functions and behavior. It goes beyond previous editions, not only in the amount of basic research that is covered, but by the inclusion of several chapters that address the clinical implications of psychoneuroimmunology for a variety of disease processes. The underlying premise, evidenced by content of this book, is that the brain and immune system represent a single, integrated system of defense.
* State-of-the-art reviews by established investigative teams
* Integrative, definitive, and multidisciplinary reviews
* Clinical and basic sciences coverage
* New directions for clinical and basic research
* Extensive references and indexing
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Dr. Ader is currently Director of the Division of Behavioral and Psychosocial Medicine and Director of the Center for Psychoneuroimmunology Research. Dr.Ader edited Psychoneuroimmunology, referred to as "the signature volume of anew field of research," and co-edited the second edition in 1991. He serves on the Editorial Board of several journals and is the Editor-in-Chief of Brain, Behavior, and Immunity. Dr. Ader is the past President of the American Psychosomatic Society, the International Society for Developmental Psychobiology, the Academy of Behvaioral Medicine Research, and Founding President of the Psychoneuroimmunology Research Society.
Dr. Felton was a co-editor ofPsychoneuroimmunology, Second Edition and Associate Editor of Brain, Behavior, and Immunity. Dr. Felton is currently Professor in the Department of Anatomy and Pathology and Director of the Center for Neuroimmunology at the Loma Linda University School of Medicine.
Dr. Cohen is currently Professor of Microbiology and Immunology and Director of the Immunology, Microbiology, and Vaccine Biology Graduate Program. He holds secondary appointments as Professor of Psychiatry and Oncology and is an Associate Director of the Center for Psychonueuroimmunology Research.
During the past two decades, there have been major efforts to understand the influence of the nervous system on immune and inflammatory responses. As a result, it has become clear that the immune system communicates with the neuroendocrine system and that imbalances in the neuroendocrine-immune circuitry are relevant to host defenses. This knowledge is the basis of the scientific discipline called psychoneuroimmunology.
The first edition of Psychoneuroimmunology was published in 1981 and helped to establish the new discipline. In addition to covering the scant amount of research on the subject that was available at that time, it contained a seminal chapter. This chapter, written by Ader and Cohen, reviewed behaviorally conditioned suppression of the immune system and provided strong support for the integration of the "somatic" and "psychological" aspects of immunity.
The table of contents of the third edition of Psychoneuroimmunology is an indication of the depth and breadth of its subject matter. Molecular biology, genetics, the neurosciences, immunology, cell biology, endocrinology, chronobiology, pharmacology, anatomy, biochemistry, and the behavioral sciences are considered. This list demonstrates that psychoneuroimmunology constitutes a meeting ground for medicine, biochemistry, genetics, psychology, and human ethology. It emphasizes the indivisibility of somatic and psychological processes and the inseparability of immunologic and neuroendocrine processes.
The first three parts of Psychoneuroimmunology deal with the pathways that bridge the brain and the immune system -- namely, the neuroendocrine and autonomic nervous systems. The primary and secondary lymphoid organs are sympathetically and parasympathetically innervated, and these types of nerve fibers form neuroeffector junctions with the lymphocytes, monocytes, macrophages, and granulocytes that possess the appropriate receptors. Several chapters in the book cover the ways in which neural and neuroendocrine signals modify immune processes and the ways in which cytokines affect brain function. One of the most valuable chapters deals with how sleep influences the homeostatic regulation of the immune system. Sleep deprivation, for example, adversely affects resistance to infectious diseases. Most of the mechanisms underlying the relation between sleep and modulation of the immune system are unknown, but it seems clear that these mechanisms are important in host defenses.
Parts IV and V of Psychoneuroimmunology document the effects of behavior and stress on immune function. Important topics, such as pain and the effects of early rearing experiences and social interactions, are covered. Psychoneuroimmunology ends with chapters, in part VI, devoted to the links between psychoneuroimmunology and neurologic and psychiatric diseases, infection, surgical trauma, cardiovascular disease, periodontal disease, alcoholism, and aging. These contributions discuss the influence of emotions on immune responsiveness and the ways in which personal and social support can help in the recovery from an immune-mediated disease.
Reading this book leaves the impression that research in psychoneuroimmunology is growing exponentially. The third edition of Psychoneuroimmunology contributes substantially to this effort.
Daniel P. Cardinali, M.D., Ph.D.
Copyright © 2001 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.
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Book Description Academic Press, 2000. Hardcover. Book Condition: Very Good. 3rd Edition. Includes both Vol. 1 and Vol. 2. Not ex-lib. Tiniest bit of scuffing at bottom of covers. Overseas/Priority shipping at cost. Bookseller Inventory # 042167