Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy (Woodhead Publishing Series in Biomaterial)

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9780081000663: Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy (Woodhead Publishing Series in Biomaterial)

Summary Most books discuss general and broad topics regarding molecular imagings. However, Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy, will mainly focus on lanthanide oxide nanoparticles for molecular imaging and therapeutics. Multi-modal imaging capabilities will discussed, along with up-converting FI by using lanthanide oxide nanoparticles. The synthesis will cover polyol synthesis of lanthanide oxide nanoparticles, Surface coatings with biocompatible and hydrophilic ligands will be discussed and TEM images and dynamic light scattering (DLS) patterns will be provided. Various techniques which are generally used in analyzing the synthesized surface coated nanoparticles will be explored and this section will also cover FT­, IR analysis, XRD analysis, SQUID analysis, cytotoxicity measurements and proton relaxivity measurements. In vivo MR images, CT images, fluorescence images will be provided and Therapeutic application of gadolinium oxide nanoparticles will be discussed. Finally, future perpectives will be discussed. That is, present status and future works needed for clinical applications of lanthanide oxide nanoparticles to molecular imagings will be discussed. About the Authors Gang Ho Lee is a professor in the Department of Chemistry at the College of Natural Sciences, Kyungpook National University, Teagu, South Korea. Tae-Jeong Kim received his BSc in and MS in Chemistry from Korea University in 1976 and 1978, and his PhD in Inorganic Chemistry from the University of British Columbia in 1984, under the supervision of Professor W R Cullen. He then joined Dr R H Fish in the Lawrence Berkeley Laboratory as a Postdoctoral fellow. After spending a year there, he began his independent career at Kyungpook National University (KNU) in 1986, where he now holds a full professorship. He is now a Professor Emeritus at KNU. His current research interests are materials and medicinal inorganic chemistry. Contents Introduction Synthesis Polyol synthesis Surface coatings Characterizations TEM measurements XRD measurements DLS measurements Ff-IR measurements TGA measurements SQUID measurements ICPAES measurements In vitro relaxivity and map image measurements In vitro cytotoxicity measurements In vivo MR image measurements Phantom image measurements Fluorescent confocal image measurements What is MRI and CT. MRI contrast agent Tl MRI contrast agents T2 MRI contrast agents CT contrast agent Multimodal imaging agents Therapeutics Future perspectives References

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About the Author:

Gang Ho Lee is a professor in the Department of Chemistry at the College of Natural Sciences, Kyungpook National University, Teagu, South Korea. Tae-Jeong Kim received his BSc in and MS in Chemistry from Korea University in 1976 and 1978, and his PhD in Inorganic Chemistry from the University of British Columbia in 1984, under the supervision of Professor W R Cullen. He then joined Dr R H Fish in the Lawrence Berkeley Laboratory as a Postdoctoral fellow. After spending a year there, he began his independent career at Kyungpook National University (KNU) in 1986, where he now holds a full professorship. He is now a Professor Emeritus at KNU. His current research interests are materials and medicinal inorganic chemistry.

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