Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing: 353 (Current Topics in Microbiology and Immunology, 353) - Softcover

9783642428173: Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing: 353 (Current Topics in Microbiology and Immunology, 353)
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"The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they  act to affect gene expression and  function.  It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property.  Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.  Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins."

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The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.  It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.

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  • PublisherSpringer
  • Publication date2014
  • ISBN 10 3642428177
  • ISBN 13 9783642428173
  • BindingPaperback
  • Number of pages248
  • EditorSamuel Charles E.

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