The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium: 233 (Advances in Anatomy, Embryology and Cell Biology, 233) - Softcover
- PublisherSpringer
- Publication date2021
- ISBN 10 3030658163
- ISBN 13 9783030658168
- BindingPaperback
- Edition number1
- Number of pages113
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The Pulmonary Neuroepithelial Body Microenvironment
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Springer International Publishing Mai 2021
(2021)
ISBN 10: 3030658163
ISBN 13: 9783030658168
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis.Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors 116 pp. Englisch. Seller Inventory # 9783030658168
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The Pulmonary Neuroepithelial Body Microenvironment
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The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium (Advances in Anatomy, Embryology and Cell Biology, 233)
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Book Description Condition: New. 1st ed. 2021 edition NO-PA16APR2015-KAP. Seller Inventory # 26387136500
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The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium
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Book Description Paperback. Condition: Brand New. 117 pages. 9.25x6.10x0.51 inches. In Stock. Seller Inventory # x-3030658163
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The Pulmonary Neuroepithelial Body Microenvironment
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Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Focuses on sensory nerves in the airwaysHighlights the multidisciplinary approach to study NEBsExplores NEBs potential as stem cell nicheDr. Inge Brouns&n. Seller Inventory # 458551731
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The Pulmonary Neuroepithelial Body Microenvironment : A Multifunctional Unit in the Airway Epithelium
Published by
Springer International Publishing
(2021)
ISBN 10: 3030658163
ISBN 13: 9783030658168
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Book Description Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis.Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors. Seller Inventory # 9783030658168
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