Clinical Trials in Oncology: 28 (Chapman & Hall/CRC Interdisciplinary Statistics) - Hardcover

Green, Stephanie; Benedetti, Jacqueline; Smith, Angela; Crowley, John

Hardcover

ISBN 10: 0412996316 ISBN 13: 9780412996313

Publisher: Chapman and Hall/CRC, 1997

Synopsis

Clinical Trials in Oncology emphasizes the importance of proper study design and data management, and explains why communication and partnership between statisticians and clinicians are vital to the conduct of a successful clinical trial. Clinicians face considerable risks-subtle and ever present-when designing trials and interpreting data. This book deals with all aspects of successful trials in a manner accessible to clinicians. Topics addressed include advantages and disadvantages of multi-arm trials; pitfalls to avoid, such as analyzing survival by response or by dose; and how and whether meta-analyses are justified.

About this title

Review:

"The dedication of the authors to enhancing the quality of clinical trials in oncology is evident from this book. This book will be useful to students, clinical research nurses and medical statisticians involved in oncology trials. I also recommend it to libraries and clinical institutions." - Clinical Trials 2004 "With over 60 years combined experience, the authors are ideally positioned to discuss the various statistical issues apparent in clinical trials, identifying alternative solutions, providing logical arguments for and against the various solutions. This book is also recommended for statisticians actively involved in the design, conduct, and analysis of clinical trial data (not only cancer clinical trials)." -Journal of Biopharmaceutical Statistics "A concise, easily readable, and thorough summaryALL medical oncology, radiation oncology, surgical oncology, and clinical research nurse academic training programs should provide this important text to trainees on Day 1." -Charles R. Thomas Jr., MD, University of Texas Health Science Center at San Antonio, USA "Succinct and focused[This book] is clear, cogent, and practical. It is structured so that statisticians can use specific sections as starting point to develop shared understandings with investigators, study coordinators, and data managersIt has been useful to me and my clients, and I look forward to the second edition." -Marlene Egger, University of Utah, USA

Synopsis:

Clinicians face considerable risks when designing trials and interpreting data. These risks are subtle and ever present. This book deals with all aspects of successful trials in a manner accessible to clinicians. After an introductory chapter, highlighted by a brief history of how clinical trials were accepted as the cornerstone of established medical practice, the authors present an overview of the statistical principles underlying the proper design of trials and the analysis of resultant data. The text emphasizes the importance of proper study design and data management, and explains why communication and partnership between statisticians and clinicians are vital to the conduct of a successful trial. Later chapters move on to cover some of the more contentious issues such as: advantages and disadvantages of multi-arm trials; when early stopping is justified; pitfalls to be avoided, such as analyzing survival by response or by dose; how and whether meta-analyses are justified. It is written for research oncologists and graduate students in biostatistics. It also provides essential information for statisticians involved with cancer clinical trials.

It should be of interest to researchers in clinical oncology trials; students in Biostatistics.

About this edition

• Publisher: Chapman and Hall/CRC
• Publication date: 1997
• ISBN 10: 0412996316
• ISBN 13: 9780412996313
• Binding: Hardcover
• Edition number: 1
• Number of pages: 216