Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease - Hardcover

9780124078253: Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease

Hardcover

ISBN 10: 0124078257 ISBN 13: 9780124078253

Publisher: Academic Press, 2014

Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets ― including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease ― are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development.

One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and disease
Experts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches
Clear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations

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Review:

Translational coverage of diet and nutrition in relation to gastrointestinal diseases

About the Author:

Kieran Tuohy received his PhD from the University of Surrey (UK) in 2000 under the supervision of Professor Ian Rowland, an MSc. in Environmental Microbiology from the University of Aberdeen, Scotland, and a BSc. in Industrial Microbiology from University College Dublin, Ireland. He worked for 10 years in the group of Professor Glenn Gibson within the Department of Food Science and Nutrition, University of Reading, first as post doctoral researcher and then as Lecturer in Food Metabonomics. His research at Reading focused on measuring the impact diet, especially probiotics and prebiotics on the human gut microbiota. In 2010 he moved to Fondazione Edmund Mach (FEM), Trento, Italy and set up a new research team working on diet:microbe interactions with a special focus on whole plant foods. He now leads the Nutrition and Nutrigenomics Group at FEM with a research focus on whole plant foods, plant bioactives, especially fiber, prebiotics and polyphenols, fermented dairy products and probiotics. He is an Associate Editor of the International Journal of Food Sciences and Nutrition, is on the scientific steering committee of the NutrEvent series of innovation events in the area of food, nutrition and health, and has been involved in a number of expert activities and events organised by the International Life Sciences Institute (ILSI) Europe and the International Scientific Association for Probiotics and Prebiotics (ISAPP).

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