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This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.
This volume includes chapters on:
- The adrenomedullin peptides and signalling
- Ligand binding and activation of the CGRP receptor
- Understanding amylin receptors
- The CGRP-receptor component protein
- The calcitonin peptide family
- Genetic regulation of CGRP
- Vascular actions of CGRP and adrenomedullin
- Intermedin/adrenomedullin 2 function
- CGRP and adrenomedullin as pain-related peptides
- Amylinergic control of ingestive behaviour
- Calcitonin receptors
This book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.
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- PublisherSpringer
- Publication date2009
- ISBN 10 9048129087
- ISBN 13 9789048129089
- BindingHardcover
- Number of pages244
- EditorHay Deborah L., Dickerson Ian M.
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The calcitonin gene-related peptide family: form, function and future perspectives [Hardcover ]
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The calcitonin gene-related peptide family
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ISBN 10: 9048129087
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Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition. 244 pp. Englisch. Seller Inventory # 9789048129089
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The calcitonin gene-related peptide family
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Book Description Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Comprehensive compilation of reviews on CGRP, amylin, calcitonin, adrenomedullin and AM2/intermedinUseful reference work for researchers in the fields of CGRP, amylin, calcitonin, adrenomedullin and AM2/intermedinIn 1925, J. B. Collip (192. Seller Inventory # 5817542
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The calcitonin gene-related peptide family : form, function and future perspectives
Published by
Springer Netherlands
(2009)
ISBN 10: 9048129087
ISBN 13: 9789048129089
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Book Description Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition. Seller Inventory # 9789048129089
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