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Despite significant progress in molecular epigenetic research and its enormous potential, there are still considerable challenges to overcome before we can fully understand the role of epigenetic processes in brain function and behavior. For instance, what comprises a ‘normal’ brain epigenome and what is the degree of region- and cellular-specificity of epigenetic landscapes in the brain? How do the multiple layers of epigenetic information interact and change over time? How common is meiotic epigenetic heritability and what role it may play in complex psychiatric disease? To what extent is the epigenome plastic and malleable in response to environmental influences? This volume demonstrates that such questions can now be explored in an experimental molecular biology laboratory. While the community is only just starting to acknowledge the importance of epigenetic processes in the brain, there is no doubt that numerous breakthrough discoveries in brain and behavioral epigenetics will be made in the decades to come.
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Book Description Hardcover. Condition: new. Seller Inventory # 9783642174254
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Art Petronis and Jon Mill s research is dedicated to the understanding of the role of epigenetic risk factors in complex diseasesEpigenetic processes can explain some of the epidemiological associations between environmental exposure and disease,. Seller Inventory # 5051429
Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical delopmental stage.Epigenetics, a cellular mechanism once considered to be stable after development, has now been found to be a dynamic process that occurs in fully differentiated, post-mitotic cells of central nervous system in response to environmental signals. Epigenetic mechanisms regulate the structure of the chromatin through post-translational modifications of histone proteins and covalent DNA modifications. Though the mechanisms through which these effects are achieved likely involve diverse cellular and molecular pathways, there is emerging evidence supporting the hypothesis that epigenetic changes, such as DNA methylation and histone modifications, may mediate the effects of early-life variations in the social interactions between mothers and infants. 336 pp. Englisch. Seller Inventory # 9783642174254
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Book Description Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical delopmental stage.Epigenetics, a cellular mechanism once considered to be stable after development, has now been found to be a dynamic process that occurs in fully differentiated, post-mitotic cells of central nervous system in response to environmental signals. Epigenetic mechanisms regulate the structure of the chromatin through post-translational modifications of histone proteins and covalent DNA modifications. Though the mechanisms through which these effects are achieved likely involve diverse cellular and molecular pathways, there is emerging evidence supporting the hypothesis that epigenetic changes, such as DNA methylation and histone modifications, may mediate the effects of early-life variations in the social interactions between mothers and infants. Seller Inventory # 9783642174254