The Aptamer Handbook: Functional Oligonucleotides and Their Applications - Hardcover

Hardcover

ISBN 10: 3527310592 ISBN 13: 9783527310593

Publisher: Wiley-VCH, 2006

Synopsis

In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes). Basic concepts and technologies describing in detail how these functional oligonucleotides can be identified are presented. Numerous examples demonstrate the versatility of in vitro selected oligonucleotides. Special emphasis has been put on a section that shows the broad applicability of aptamers, e. g. in target validation, for analytics, or as new therapeutics. This first overview in the field is of prime interest for a broad audience of scientists both in academia and in industry who wish to expand their knowledge on the potential of new oligonucleotide functions and their applications.

About this title

Review:

"Considering the overall effort by the editor to gather work by some of the leading researchers on aptamers, I believe The Aptamer Handbook will be referred to as an encyclopedia on aptamer research. This book would most likely appeal to someone who has interest in combinatorial libraries, nucleic acids, and biosensors. Therefore, it would be an excellent addition to the libraries of universities, institutes, and industry, given the diverse aptamer applications in various fields." ChemBioChem

"Overall, this is an outstanding book and it will deservedly become the resource of choice for the growing legion of researchers in the aptamer field. Clear illustrations, extensive reference lists for each chapter, and a detailed index supplement the excellent writing. Students and faculty members at all levels will benefit from reading selected chapters in isolation, or from methodically reading the entire book."
Angewandte Chemie

About the Author:

Sven Klussmann is co-founder and Chief Scientific Officer of NOXXON Pharma AG, Berlin. He is a Biochemist by training and his initial studies were carried out at the Freie Universitat Berlin, where he obtained his academic degrees. Dr. Klussmann received the Carl Ramsauer Award for his dissertation in which he demonstrated the principles of the Spiegelmer Technology, a new approach to identify biostable mirror-image oligonucleotides (so-called Spiegelmers) that can bind with high affinity to target molecules. He has authored more than 30 articles and 40 patents on oligonucleotides and their applications.

About this edition

• Publisher: Wiley-VCH
• Publication date: 2006
• ISBN 10: 3527310592
• ISBN 13: 9783527310593
• Binding: Hardcover
• Edition number: 1
• Number of pages: 518
• Editor: Klussmann Sven