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Published by Berlin, Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Antiquariat Bookfarm, Löbnitz, Germany
Book
Hardcover. 331 S. Ehem. Bibliotheksexemplar mit Signatur und Stempel. GUTER Zustand, ein paar Gebrauchsspuren. Ex-library with stamp and library-signature. GOOD condition, some traces of use. 9783540690368 Sprache: Englisch Gewicht in Gramm: 550.
Published by Springer, Germany, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: The Book Exchange, Macclesfield, United Kingdom
Book
Hardcover. Condition: Near Fine. No Jacket. 9783540690368. Unread hardcover, from closed pharmaceutical company library. English text. 342 pages, Subject Index, illustrated with charts, tables and diagrams. Sections: Macrolide-Based Microtubule-Stabilizing Agents - Chemistry and Structure-Activity Relationships; The Chemical Synthesis of Discodermolide; The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels; The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR; The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography; Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin; Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents. Contents unread, looks like new, clean, tight and bright. Book.
Published by Springer, 2009
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: Anybook.com, Lincoln, United Kingdom
Book
Condition: Good. Volume 286. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. Clean from markings. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,650grams, ISBN:9783642435942.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Studibuch, Stuttgart, Germany
Book
hardcover. Condition: Sehr gut. 342 Seiten; 9783540690368.2 Sprache: Deutsch Gewicht in Gramm: 1.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Michener & Rutledge Booksellers, Inc., Baldwin City, KS, U.S.A.
Book
Hardcover. Condition: Very Good+. Text clean and tight; no dust jacket; Topics in Current Chemistry 286; 0.9 x 9.3 x 6.3 Inches; 342 pages.
Published by Humana, 2023
ISBN 10: 1071633929ISBN 13: 9781071633922
Seller: booksXpress, Bayonne, NJ, U.S.A.
Book
Hardcover. Condition: new.
Published by Springer, Berlin|Springer US|Humana, 2023
ISBN 10: 1071633929ISBN 13: 9781071633922
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynam.
Published by Springer US Okt 2023, 2023
ISBN 10: 1071633929ISBN 13: 9781071633922
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains by measuring or calculating their affinity to phosphopeptides. Part Three focuses on inhibitors of SH2 domains that lead the way for chemical tool development and drug discovery. Part Four describes how to evolve and engineer SH2 domains with specific binding properties, and Part Five explores how to measure the regulation of protein tyrosine phosphatase activity through allosteric binding of peptides to SH2 domains and condensation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, SH2 Domains: Functional Modules and Evolving Tools in Biology is a valuable resource for researchers, working in the biophysical and biochemical field, who want to learn more about this exciting and versatile class of regulatory and signaling domains. 396 pp. Englisch.
Published by Springer US, 2023
ISBN 10: 1071633929ISBN 13: 9781071633922
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains by measuring or calculating their affinity to phosphopeptides. Part Three focuses on inhibitors of SH2 domains that lead the way for chemical tool development and drug discovery. Part Four describes how to evolve and engineer SH2 domains with specific binding properties, and Part Five explores how to measure the regulation of protein tyrosine phosphatase activity through allosteric binding of peptides to SH2 domains and condensation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, SH2 Domains: Functional Modules and Evolving Tools in Biology is a valuable resource for researchers, working in the biophysical and biochemical field, who want to learn more about this exciting and versatile class of regulatory and signaling domains.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Basi6 International, Irving, TX, U.S.A.
Book
Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
Published by Springer-Verlag New York Inc., New York, NY, 2023
ISBN 10: 1071633929ISBN 13: 9781071633922
Seller: Grand Eagle Retail, Wilmington, DE, U.S.A.
Book First Edition
Hardcover. Condition: new. Hardcover. This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains by measuring or calculating their affinity to phosphopeptides. Part Three focuses on inhibitors of SH2 domains that lead the way for chemical tool development and drug discovery. Part Four describes how to evolve and engineer SH2 domains with specific binding properties, and Part Five explores how to measure the regulation of protein tyrosine phosphatase activity through allosteric binding of peptides to SH2 domains and condensation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, SH2 Domains: Functional Modules and Evolving Tools in Biology is a valuable resource for researchers, working in the biophysical and biochemical field, who want to learn more about this exciting and versatile class of regulatory and signaling domains. Part Four describes how to evolve and engineer SH2 domains with specific binding properties, and Part Five explores how to measure the regulation of protein tyrosine phosphatase activity through allosteric binding of peptides to SH2 domains and condensation. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Published by Springer, 2014
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: booksXpress, Bayonne, NJ, U.S.A.
Book
Soft Cover. Condition: new.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: booksXpress, Bayonne, NJ, U.S.A.
Book
Hardcover. Condition: new.
Published by Springer, 2014
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Book Print on Demand
Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Book Print on Demand
Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Published by Springer, 2014
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Book
Condition: New.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Book
Condition: New.
Published by Springer Berlin Heidelberg Nov 2014, 2014
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology. 344 pp. Englisch.
Published by Springer Berlin Heidelberg, 2014
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Books Puddle, New York, NY, U.S.A.
Book
Condition: New. pp. 344.
Published by Springer, 2009
ISBN 10: 3540690360ISBN 13: 9783540690368
Seller: Majestic Books, Hounslow, United Kingdom
Book
Condition: New. pp. 344 98 Illus. (68 Col.).
Published by Springer, 2014
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: Books Puddle, New York, NY, U.S.A.
Book
Condition: New.
Published by Springer, 2014
ISBN 10: 3642435947ISBN 13: 9783642435942
Seller: Majestic Books, Hounslow, United Kingdom
Book Print on Demand
Condition: New. Print on Demand.