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Tubulin-Binding Agents

Teresa Carlomagno

Published by Springer-Verlag Gmbh Jun 2009, 2009
ISBN 10: 3540690360 / ISBN 13: 9783540690368
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Title: Tubulin-Binding Agents

Publisher: Springer-Verlag Gmbh Jun 2009

Publication Date: 2009

Binding: Buch

Book Condition: Neu


Neuware - reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a 'time-resolved' picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology. 331 pp. Englisch. Bookseller Inventory # 9783540690368

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Synopsis: Bernhard Pfeiffer, Christian N. Kuzniewski, Christoph Wullschleger, and Karl-Heinz Altmann: Macrolide-Based Microtubule-Stabilizing Agents - Chemistry and Structure-Activity Relationships.- Ian Paterson and Gordon J. Florence: The Chemical Synthesis of Discodermolide.- J. Fernando Díaz, José Manuel Andreu, and Jesús Jiménez-Barbero: The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels.- Víctor M. Sánchez-Pedregal, and Christian Griesinger: The Tubulin-Binding Mode of MT Stabilizing and Destabilizing Agents studied by NMR.- James H. Nettles and Kenneth H. Downing: The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography.- Benoit Gigant, Anthony Cormier, Audrey Dorleans, Raimond B. G. Ravelli, Marcel Knossow: Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin.- Maurizio Botta, Stefano Forli, Matteo Magnani, Fabrizio Manetti: Molecular Modelling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents

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