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Telomeres and Telomerase in Cancer

Keiko Hiyama

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ISBN 10: 1603273069 / ISBN 13: 9781603273060
Published by Springer-Verlag Gmbh Feb 2009, 2009
New Condition: Neu
From Agrios-Buch (Bergisch Gladbach, Germany)

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Neuware - Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in 'cancer stem cells' has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge. 373 pp. Englisch. Bookseller Inventory # 9781603273060

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Bibliographic Details

Title: Telomeres and Telomerase in Cancer

Publisher: Springer-Verlag Gmbh Feb 2009

Publication Date: 2009

Binding: Buch

Book Condition:Neu

About this title

Synopsis:

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

From the Back Cover:

Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.

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