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Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Lucio Annunziato

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ISBN 10: 1461447550 / ISBN 13: 9781461447559
Published by Springer-Verlag Gmbh Dez 2012, 2012
New Condition Neu Buch
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Neuware - This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract. The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE. 463 pp. Englisch. Bookseller Inventory # 9781461447559

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Synopsis:

This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011.

The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.

The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.

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?It collects in one place state-of-the-art information on all facets of the structure and function of sodium calcium exchangers in biological systems with a special focus on pathophysiological implications. ? This will be of most value to research scientists, including students, whose research involves studying the mechanisms for maintaining ion homeostasis in biological systems. ? I highly recommend it to all researchers who work in the field of ion homeostasis.? (Thomas L. Pazdernik, Doody's Book Reviews, March, 2013)

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Bibliographic Details

Title: Sodium Calcium Exchange: A Growing Spectrum ...

Publisher: Springer-Verlag Gmbh Dez 2012

Publication Date: 2012

Binding: Buch

Book Condition: Neu

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