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Skin rash to HER inhibitors in cancer patients: Histopathologic and immunohistochemical characterization

Beatrice Nardone

ISBN 10: 3659297585 / ISBN 13: 9783659297588
Published by LAP LAMBERT Academic Publishing, 2012
Condition: Good Soft cover
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Bibliographic Details

Title: Skin rash to HER inhibitors in cancer ...

Publisher: LAP LAMBERT Academic Publishing

Publication Date: 2012

Binding: Paperback

Book Condition: Good

About this title

Synopsis:

Human epidermal receptor (HER) 1 inhibitors and HER 1/2 inhibitors have shown benefit against a wide range of solid tumors. However, their use is associated with skin rash in 40-90% of patients, which impacts quality of life and interrupts antineoplastic therapy. The pathologic characteristics of affected skin remain unclear, precluding development of rational therapies. The aim of this study is to evaluate differences in histologic and immunohistochemical (IHC) alterations in rash caused by lapatinib, a dual HER1/2 inhibitor (HER1/2i), and the single HER1 inhibitors (HER1i) cetuximab, erlotinib, and panitumumab. We found a lower inhibition of epidermal kinetics and decreased inflammation in HER1/2i-induced rash. These findings underscore differences in skin toxicity as related to specificity of HER blockade, concordant with clinical tolerability and decreased severity of skin toxicity seen with the HER1/2i lapatinib compared to the HER1 inhibitors cetuximab, erlotinib and panitumumab.

About the Author:

She received her MD from University of Catania (Italy), where she completed her Dermatology residency and earned her PhD in Preclinical and Clinical Pharmacology. She spent 2 years as PhD student at Northwestern University. She is currently appointed as Clinical Research Associate at Department of Dermatology, Northwestern University, Chicago.

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