Stock Image

Skin rash to HER inhibitors in cancer patients: Histopathologic and immunohistochemical characterization

Beatrice Nardone

ISBN 10: 3659297585 / ISBN 13: 9783659297588
Published by LAP LAMBERT Academic Publishing, 2012
Condition: Good Soft cover
From Books Express (Portsmouth, NH, U.S.A.)

AbeBooks Seller Since 14 August 2015 Seller Rating 5-star rating

Quantity Available: 1

Buy Used
Price: 152.40 Convert Currency
Shipping: Free Within U.S.A. Destination, rates & speeds
Add to basket

About this Item

Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May not contain Access Codes or Supplements. May be ex-library. Shipping & Handling by region. Buy with confidence, excellent customer service!. Bookseller Inventory # 3659297585

Ask Seller a Question

Bibliographic Details

Title: Skin rash to HER inhibitors in cancer ...

Publisher: LAP LAMBERT Academic Publishing

Publication Date: 2012

Binding: Paperback

Book Condition: Good

About this title


Human epidermal receptor (HER) 1 inhibitors and HER 1/2 inhibitors have shown benefit against a wide range of solid tumors. However, their use is associated with skin rash in 40-90% of patients, which impacts quality of life and interrupts antineoplastic therapy. The pathologic characteristics of affected skin remain unclear, precluding development of rational therapies. The aim of this study is to evaluate differences in histologic and immunohistochemical (IHC) alterations in rash caused by lapatinib, a dual HER1/2 inhibitor (HER1/2i), and the single HER1 inhibitors (HER1i) cetuximab, erlotinib, and panitumumab. We found a lower inhibition of epidermal kinetics and decreased inflammation in HER1/2i-induced rash. These findings underscore differences in skin toxicity as related to specificity of HER blockade, concordant with clinical tolerability and decreased severity of skin toxicity seen with the HER1/2i lapatinib compared to the HER1 inhibitors cetuximab, erlotinib and panitumumab.

About the Author:

She received her MD from University of Catania (Italy), where she completed her Dermatology residency and earned her PhD in Preclinical and Clinical Pharmacology. She spent 2 years as PhD student at Northwestern University. She is currently appointed as Clinical Research Associate at Department of Dermatology, Northwestern University, Chicago.

"About this title" may belong to another edition of this title.

Store Description

Visit Seller's Storefront

Terms of Sale:

Buy with confidence. Excellent customer service. 30 day return policy.

Books Express LLC
318 US Route 1, STE 2
Kittery ME 03904

Shipping Terms:

Default shipping is by USPS Media Mail and frequently USPS Priority Mail or UPS Ground is used. Books should arrive within 5-45 business days for expedited shipping, and 7-60 business days for standard shipping. Standard shipping can on occasion take up to 60 days for delivery.

List this Seller's Books

Payment Methods
accepted by seller

Visa Mastercard American Express

Check Money Order PayPal Invoice Bank Draft Bank/Wire Transfer Direct Debit (Personally Authorized Payment)