Population Pharmacokinetic Modelling and Simulation of Monoclonal Antibodies Including the Impact of Immunogenicity and Importance of Study and Analysis Design Factors

Ronald Niebecker

Published by Shaker Verlag Mrz 2014, 2014
ISBN 10: 3844026509 / ISBN 13: 9783844026504
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Neuware - In the present thesis, pharmacometric modelling methodologies were applied to determine the pharmacokinetics of sibrotuzumab, a humanised therapeutic monoclonal antibody, and to account for the in uence of immunogenicity. Furthermore, design factors in uencing the identi ability of model parameters characterising monoclonal antibody pharmacokinetics were investigated using a simulation-based approach. 262 pp. Englisch. Bookseller Inventory # 9783844026504

Bibliographic Details

Title: Population Pharmacokinetic Modelling and ...
Publisher: Shaker Verlag Mrz 2014
Publication Date: 2014
Binding: Taschenbuch
Book Condition: Neu

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