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Phosphodiesterases as Drug Targets

Sharron H. Francis

Published by Springer-Verlag Gmbh Aug 2011, 2011
ISBN 10: 3642179681 / ISBN 13: 9783642179686
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Title: Phosphodiesterases as Drug Targets

Publisher: Springer-Verlag Gmbh Aug 2011

Publication Date: 2011

Binding: Buch

Book Condition: Neu

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Neuware - Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. 519 pp. Englisch. Bookseller Inventory # 9783642179686

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Synopsis: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

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