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Lead-Seeking Approaches

Matthew M. Hayward

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ISBN 10: 3642010741 / ISBN 13: 9783642010743
Published by Springer-Verlag Gmbh Okt 2009, 2009
New Condition: Neu
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Neuware - High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi cation of leads is an essential part of drug discovery. The process for the identi cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi ed from one or more of these screening methods, they need to be thoroughly characterized in order to con rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi ed, preliminary optimization through synthetic modi cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef cient approach to the identi cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi - tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci c points. There are also a number of excellent reviews covering the lead identi cation process [1-6]. 217 pp. Englisch. Bookseller Inventory # 9783642010743

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Title: Lead-Seeking Approaches

Publisher: Springer-Verlag Gmbh Okt 2009

Publication Date: 2009

Binding: Buch

Book Condition:Neu

About this title

Synopsis:

High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [1–6].

From the Back Cover:

Christopher A. Lipinski: Overview of Hit to Lead: The Medicinal Chemist’s Role from HTS Retest to Lead Optimization Hand Off

Jeff W. Paslay · John E. Morin · Richard K. Harrison: High Throughput Screening in the Twenty - First Century

Jack Andrew Bikker · Lakshmi S.Narasimhan: Lead Discovery Using Virtual Screening

Maurizio Pellecchia: NMR Spectroscopy in Fragment Based Drug Design

Kevin D. Freeman-Cook · Daniel W. Kung: Hit Triage – Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery

John W. Ellingboe · Adam M. Gilbert: Lead Identification

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