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Inhibitory Regulation of Excitatory Neurotransmission

Mark G. Darlison

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ISBN 10: 3540726012 / ISBN 13: 9783540726012
Published by Springer-Verlag Gmbh Okt 2007, 2007
New Condition: Neu
From Agrios-Buch (Bergisch Gladbach, Germany)

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Neuware - Darlison's excellent work reviews aspects of GABA-A receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABA-C receptors and G-protein coupled receptors including neuropeptides. Glycine receptors and potassium channels are covered too. The consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are also discussed. 248 pp. Englisch. Bookseller Inventory # 9783540726012

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Bibliographic Details

Title: Inhibitory Regulation of Excitatory ...

Publisher: Springer-Verlag Gmbh Okt 2007

Publication Date: 2007

Binding: Buch

Book Condition:Neu

About this title

Synopsis:

Darlison’s excellent work reviews aspects of GABA-A receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABA-C receptors and G-protein coupled receptors including neuropeptides. Glycine receptors and potassium channels are covered too. The consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are also discussed.

From the Back Cover:

Within the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-synaptic GABAA receptors, many other proteins and mechanisms regulate excitation. These exist both to "fine tune" neurotransmission and to prevent overexcitation that could lead to conditions such as epilepsy and excitotoxicity, which can result in cell death. This book reviews aspects of GABAA receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABAC receptors, G-protein coupled receptors (specifically, GABAB receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed.

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