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Imaging the Brain with Optical Methods

Anna W. Roe

Published by Springer-Verlag Gmbh Dez 2010, 2010
ISBN 10: 1441904514 / ISBN 13: 9781441904515
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Title: Imaging the Brain with Optical Methods

Publisher: Springer-Verlag Gmbh Dez 2010

Publication Date: 2010

Binding: Buch

Book Condition: Neu

Description:

Neuware - Monitoring brain function with light in vivo has become a reality. The technology 33 of detecting and interpreting patterns of reflected light has reached a degree of 34 maturity that now permits high spatial and temporal resolution visualization at both 35 the systems and cellular levels. There now exist several optical imaging methodolo- 36 gies, based on either hemodynamic changes in nervous tissue or neurally induced 37 light scattering changes, that can be used to measure ongoing activity in the brain. 38 These include the techniques of intrinsic signal optical imaging, near-infrared optical 39 imaging, fast optical imaging based on scattered light, optical imaging with voltage 40 sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of 41 this volume is to capture some of the latest applications of these methodologies to 42 the study of cerebral cortical function. 43 This volume begins with an overview and history of optical imaging and its use 44 in the study of brain function. Several chapters are devoted to the method of intrin- 45 sic signal optical imaging, a method used to record the minute changes in optical 46 absorption due to hemodynamic changes that accompanies cortical activity. Since the 47 detected hemodynamic changes are highly localized, this method has excellent 48 spatial resolution (50-100 µm ), a resolution sufficient for visualization of fundamen- 49 tal modules of cerebral cortical function. 259 pp. Englisch. Bookseller Inventory # 9781441904515

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Synopsis: The technology of detecting and interpreting patterns of reflected light has reached a remarkable degree of maturity that now permits high spatial and temporal resolution visualization at both the systems and cellular levels. There now exist several optical imaging methodologies, based on either hemodynamic changes in nervous tissue or neurally-induced light scattering changes, that can be used to measure ongoing activity in the brain. In two parts, Imaging the Brain with Optical Methods discusses the history of optical imaging and its use in the study of brain function, and the rapidly developing optical technologies and their applications that have recently developed. These include intrinsic signal optical imaging, near-infrared optical imaging, fast optical imaging based on scattered light, optical imaging with voltage sensitive dyes, and 2 photon imaging of hemodynamic signals. In total, this volume will encapsulate the current state of optical imaging methodologies and their contribution towards understanding the spatial and temporal organization of cerebral cortical function.

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