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G-Protein-Coupled Receptors as Drug Targets

Roland Seifert

Published by Wiley VCH Verlag Gmbh Sep 2005, 2005
ISBN 10: 3527308199 / ISBN 13: 9783527308194
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Title: G-Protein-Coupled Receptors as Drug Targets

Publisher: Wiley VCH Verlag Gmbh Sep 2005

Publication Date: 2005

Binding: Buch

Book Condition: Neu

Description:

Neuware - With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._The chaptes are all cross-referenced with each other and cover general mechnisms, methodological approaches and cover selected important GPCR sysstems, the consequences for drug action, including, side effects, and rational drug design for GPCR targets. A highly recommended reference for researchers in academia and industry. authors addresses in detail current models and concepts, so as to introduce pharmaceutical chemists, physiologists and medical researchers to the advances in the understanding of GPCR activation and constitutive activity, and provides an overview of the methods of investigating GPCR activity. The text is backed by abundant case studies and methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, and rational drug design for GPCR targets. A highly practical reference for researchers in academia and industry. 275 pp. Englisch. Bookseller Inventory # 9783527308194

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Críticas: "...an excellent review of the body of evidence describing constitutive GPCR activity...a good addition to personal or departmental libraries of many basic scientists." (Journal of Medicinial Chemistry, August 10, 2006)

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