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Epigenetics and Disease

Susan Gasser

Published by Springer Basel AG Dez 2010, 2010
ISBN 10: 3764389885 / ISBN 13: 9783764389888
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Title: Epigenetics and Disease

Publisher: Springer Basel AG Dez 2010

Publication Date: 2010

Binding: Buch

Book Condition: Neu

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Neuware - Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. 270 pp. Englisch. Bookseller Inventory # 9783764389888

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Synopsis: Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications are potentially heritable but reversible alterations in gene expression which determine the fate of cells and therefore play a role in diseases, including cancer and neuronal disorders.The great interest in this regulatory system results from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, are currently undergoing clinical trials. This volume highlights the results of such studies, including the epigenetic control of gene expression and post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs (miRNSs) as well as new findings from stem cell research which are relevant to pharmacological applications.

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