Synopsis
Third Edition entitled "Aromatic Hydroxyketones: Preparation and Physical Properties" to be published in 2010 as a 4-volume handbook set including: Vol. 1: "Hydroxybenzophenones"; Vol. 2: "Hydroxyacetophenones I"; Vol. 3: "Hydroxyacetophenones II"; and Vol. 4: "Hydroxypropiophenones, Hydroxyisobutyrophenones, Hydroxypivalophenones, and Derivatives". Hydroxyacetophenones constitute the starting material for a wide variety of syntheses in organic chemistry. They are versatile building blocks serving many different applications, such as specialty polymers, pharmaceuticals and fine chemicals. In this Handbook, the diverse ways of obtaining over 3000 hydroxyacetophenones are described and their physico-chemical properties and spectroscopic data references are indicated. The Handbook is presented in dictionary style, with a logical classification of the ketones, making the information easily available for consultation. Ketones are classified methodically. They are thus easily accessible from three tables: the molecular formula index; the chemical abstracts registry; and the usual names index. This completely revised and enlarged edition includes: 10 additional chapters compared with the previous edition which had just 2 chapters; an additional 1500 ketones; updated information for ~1200 ketone entries; and the addition of di- and polyketones - approximately 3500 references. This Handbook is the reference on hydroxyacetophenones. It is a powerful synthesis tool for the researcher or industrial producers. Nowhere else are so many compounds covered or the physical properties and relevant syntheses provided. It provides a wide choice of hydroxyketones required to achieve syntheses based upon this range of intermediates.
Review
From the Foreword... When Dr Martin asked me to write a Foreword for his new handbook, I was really enthusiastic. Indeed I met Dr Martin for the first time when joining the Institute Curie at the beginning of the 1990's to take the direction of the team of medicinal chemists. At that time Dr Martin was retired from the Sanofi company but was working at the bench from early in the morning to late in the evening like a young and brilliant student. He devoted all his time and energy to make complete the description of what constitutes the subject of his published handbooks. Tireless reader of a huge lot of periodicals, he collected, day after day, a large amount of data about the hydroxyacetophenones and the hydroxybenzophenones. As a continuation of this already published two handbooks of both classes of compounds, Dr Martin now takes care of substituted hydroxyacetophenones. As these new collected compounds have been added to the unsubstituted analogs, one can say that this book constitutes and enlarged second edition of the first hydroxyacetophenone handbook. Not less than 3000 molecules and 3500 references can be found in this new volume. The presentation is the same as in the first two volumes with consistent data on the synthetic route or on the natural origin or each compound, and their physicochemical and spectroscopic characteristics available in the literature. I am sure that, even at the internet era, this handbook will be helpful for the readers concerned by the use of these compounds in all the aspects of chemistry covering pharmaceutical, agrochemical, perfume, plastic preservatives domains or elaboration of small libraries of organic compounds for biological screening. Besides, consulting such a handbook is greatly facilitated by the presence of three comprehensive tables, including CAS number, official nomenclature and usual names. This will be helpful to the reader and I am sure that this book will meet the success it deserves. Claude Monneret, Research Director at the CNRS
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