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Controlled Clinical Trials in Neurological Disease (Foundations of Neurology)

Springer / Kluwer Academic Publishers

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ISBN 10: 0792306139 / ISBN 13: 9780792306139
Published by Springer / Kluwer Academic Publishers, 1990
New Condition: New Hardcover
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Bibliographic Details

Title: Controlled Clinical Trials in Neurological ...

Publisher: Springer / Kluwer Academic Publishers

Publication Date: 1990

Binding: Hardcover

Book Condition: New

Edition: 1990.

About this title


The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im­ portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru­ ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and their statistical colleagues: this is the controlled clinical trial. During the past two decades, the evaluation of clinical approaches to pre­ vention and therapy has become particularly important to clinicians concerned with nervous system dysfunction. There has been and continues to be an explosion of information from the basic neurosciences and from the applica­ tion of biotechnology to the nervous system.


`Cet ouvrage, rédigée par de nombreux experts et d'une manière fort critique, est certainement très précieux. Il mérite d'être lu et médité.'
Acta Neurologica, 90, 1990

` ... for any serious researcher. The book is recommended for all health care professionals who have an interest in neurological neurosurgical or neurorehabilitative research.'
Brain Injury, 7:1

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