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Combinatorial Chemistry on Solid Supports

Stefan Bräse

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ISBN 10: 3540725091 / ISBN 13: 9783540725091
Published by Springer-Verlag Gmbh Jul 2007, 2007
New Condition: Neu
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Neuware - Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980s, this methodology was explored extensively in the 1990s by groups in academia and in industry. Without any doubt, combinatorial chemistry changed the whole drug-discovery process and found many applications in cropscience and the material sciences. However, since its implementation, solution- and solid-phase techniques have been competing with each other, and although many companies started theircombinatorialchemistryprogramwithsolid-phasetechniques,soluti- phase combinatorial methods have taken over and now account for appro- mately 25% of all combinatorial efforts. The syntheses of complex, non-polymeric structures, discovered in the 1960s by the late Bruce Merri eld, was largely ignored in the context of solid supports, mainly due to the fact that appropriate synthesis techniques were not available. Since solid-phase chemical methodology strongly differs from traditional solution-phase chemistry, two chapters deal with this topic. The Bräse group (Jung, Wiehn, Bräse) gives an overview of multifunctional linkers, which can beusedforthegenerationofdiversity-orientedcollections,simplybycleavage fromresins. Still in its infancy, solid-phase reactions employ simple amide chemistry in most cases due to their high-yielding, reliable protocols. Ljungdahl, Br- eld, and Kann address solid-phase organometallic chemistry, which is now one ofthe great challenges in reliable solid-phase organicsynthesis. 360 pp. Englisch. Bookseller Inventory # 9783540725091

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Title: Combinatorial Chemistry on Solid Supports

Publisher: Springer-Verlag Gmbh Jul 2007

Publication Date: 2007

Binding: Buch

Book Condition:Neu

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With contributions by numerous experts

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"This book, written by an international group of renowned experts in their respective field, covers recent advances in important topics regarding combinatorial chemistry on solid supports. ... It will be a useful addition to the review literature and should be of interest to a significant segment of colleagues working in SPOC." (Rolando Perez-Pineiro and Hicham Fenniri, JACS, Vol. 130 (13), 2008)

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