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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential (Current Topics in Microbiology and Immunology)


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ISBN 10: 3540244441 / ISBN 13: 9783540244448
Published by Springer, 2005
New Condition: New Hardcover
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Title: CD4+CD25+ Regulatory T Cells: Origin, ...

Publisher: Springer

Publication Date: 2005

Binding: Hardcover

Book Condition:New

Edition: 2005.

About this title


The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituentsthuspreservingitsintegrity. Multiplemechanismsactinconcert to ensure self-tolerance. During intrathymic development, the nascent T cell repertoire is purged from autoreactive T cells via negative selection, a process also known as recessive tolerance. Ridding of self-reactivity, however,isnotcomplete,asattestedbythepresenceofself-reactiveTcells intheperipheralTcellrepertoire. Hence,additionaltolerancemechanisms, collectively referred to as dominant tolerance, have been postulated on theoreticalgrounds(seethechapterbyA. Coutinhoetal. inthisvolume)and experimentalprooffortheirexistencehadbeenrepeatedlyclaimedinthepast 40years. Whilesomeoftheseclaims,largelybasedoninvitroexperiments, laterfellintodisrepute(i. e. ,theinfamousCD8suppressorcellsexpressingI-J molecules),concurrent,butlesswellpublicizedstringsofresearch,provided unremitting evidence for dominant tolerance mechanisms. These include the postnatal thymectomy model pioneered by Nishizuka and Sakakura in 1969, the dominant tolerance model in chicken and quail chimeras introducedbyleDouarinandcolleagues,andstudiesoninfectioustolerance by the Waldmann laboratory. A breakthrough in this ?eld was achieved by the identi?cation and isolation by Sakaguchi's and Shevach's groups of + + aCD4 CD25 TcellsubsetexertingsuppressiononeffectorTcellsbothin vitroandinvivo. Thisinstigatedanavalancheofpublicationsonsuppressor Tcells. Whilelargelyoverlookedforsomanyyears,thereisnowhardlyany aspectofimmunitythatdoesnotseemtobeaffectedbysuppressorTcells. This volume will hardly be more than a snapshot in thisfast-moving ?eld, yetwehopethatitwillofferinspirationandorientationtothescientistwho wouldliketoenterthis?eld. To date, many different cells have been described that can suppress + + other cells of the immune system: CD4 CD25 regulatory T cells (Treg), + ? CD4 CD25 regulatory T cells, T regulatory 1 cells (Tr1), T-helper 3 cells + ? (Th3),CD8 CD28 Tcells,NKTcells,aswellastolerogenicdendriticcells. Suppressive CD4 T cells fall at least into two categories. So called natural VI Preface + + CD4 CD25 Tregformpartoftheintra-thymicallyselectedTcellrepertoire andapparentlyconstituteadistinctlineage. Incontrast,"adaptive"regulatory Tcellsareinstructedintheperipherytobecomesuppressivecells,theyform + + amoreheterogeneousgroupincludingCD4 CD25 Treg,Tr1,andTh3cells. As natural Treg are so far the best characterized entity, the ?rst three contributionsofthisvolume(C. Cozzoetal. ,C. -S. Hsiehetal. ,andL.

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The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival.

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