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Bone and Osteoarthritis

Felix Bronner

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ISBN 10: 1846285135 / ISBN 13: 9781846285134
Published by Springer-Verlag Gmbh Okt 2007, 2007
New Condition: Neu
From Agrios-Buch (Bergisch Gladbach, Germany)

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Neuware - The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic. Advances in bone and joint biology enable practitioners to approach clinical problems more comprehensively. Emphasis on genetics and on newer viewpoints and approaches, exemplified by the possible effect of subchondral bone on osteoarthritis, gives a wider viewpoint to the reader and may enable novel approaches to solving a clinical problem. 218 pp. Englisch. Bookseller Inventory # 9781846285134

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Bibliographic Details

Title: Bone and Osteoarthritis

Publisher: Springer-Verlag Gmbh Okt 2007

Publication Date: 2007

Binding: Buch

Book Condition:Neu

About this title

Synopsis:

The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic. Advances in bone and joint biology enable practitioners to approach clinical problems more comprehensively. Emphasis on genetics and on newer viewpoints and approaches, exemplified by the possible effect of subchondral bone on osteoarthritis, gives a wider viewpoint to the reader and may enable novel approaches to solving a clinical problem.

From the Back Cover:

Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease.

A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis.

Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury.

Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology.

This book, intended for clinicians, researchers and students, provides information that will orient the novice and update the specialist. No other book treats the relationship of bone to osteoarthritis in similar fashion or provides a comparable underpinning of joint pathophysiology.

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