BioNMR in Drug Research, Volume 16 (Methods and Principles in Medicinal Chemistry)

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ISBN 10: 3527304657 / ISBN 13: 9783527304653
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Synopsis: The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids.
BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies.
With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.

Review: "The editor has managed to recruit a team of well-recognized experts as authors for this book, thereby ensuring a high standard of reliable and objective reporting. The book is not only of interest to specialists in pharmaceutical research and development, but will certainly also be a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their application to biomolecules"
(Angewandte Chemie Int. Ed.)

"The book presents a good overview of state-of-the-art NMR techniques in drug discovery. [...] It is suggested reading for people involved in pharmaceutical research as well as academic researchers with an interest in drug discovery."
(ChemBioChem)

"...certainly a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their applications..." Angewandte Chemie Int. Edition

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Title: BioNMR in Drug Research, Volume 16 (Methods ...
Publisher: Wiley-VCH
Binding: Hardcover
Book Condition: New

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Oliver Zerbe
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Book Description Wiley, Germany, 2003. Hardcover. Book Condition: Fine. Pharmaceutical company library, laminated, pictorial board hardcover. Lending record shows this book has never been borrowed. 484 pages, index, illustrated with charts, tables and diagrams. Presents the background on NMR of biomolecules, plus the use of NMR techniques in determining structure of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. This interaction can now be displayed in 3D. Methods for characterizing substance receptor complexes are demonstrated with case studies from pharmaceutical research. An invaluable guide for NMR spectroscopists and pharmaceutical researchers. Contents as new, clean, tight and bright. Book. Bookseller Inventory # 16235

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Editor: Oliver Zerbe (ETH Zürich, Switzerland); Series Editor: Raimund Mannhold (University of Düsseldorf, Germany); Series Editor: Hugo Kubinyi (BASF AG, Ludwigshafen, Germany); Series Editor: Gerd Folkers (ETH Zürich, Switzerland)
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Oliver Zerbe (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)
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Book Description Wiley VCH Verlag Gmbh Nov 2002, 2002. Buch. Book Condition: Neu. 530x250x190 mm. Neuware - Durch die großen Fortschritte in der Untersuchung von Biomolekülen durch NMR in den letzten Jahren steht mit der NMR-Spektroskopie ein universell einsetzbares Werkzeug zur Untersuchung der Bindung eines Wirkstoffs an sein Zielprotein zur Verfügung, von dessen Einsatz insbesondere die Arzneistoffentwicklung profitiert. Diese Wechselwirkung kann heute mittels NMR in unübertroffener Genauigkeit untersucht und räumlich dargestellt werden; eine wichtige Vorbedingung für die gezielte Entwicklung von neuen Wirkstoffen. 480 pp. Deutsch. Bookseller Inventory # 9783527304653

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Book Description Wiley VCH Verlag Gmbh Nov 2002, 2002. Buch. Book Condition: Neu. 240x170x380 mm. Neuware - Durch die großen Fortschritte in der Untersuchung von Biomolekülen durch NMR in den letzten Jahren steht mit der NMR-Spektroskopie ein universell einsetzbares Werkzeug zur Untersuchung der Bindung eines Wirkstoffs an sein Zielprotein zur Verfügung, von dessen Einsatz insbesondere die Arzneistoffentwicklung profitiert. Diese Wechselwirkung kann heute mittels NMR in unübertroffener Genauigkeit untersucht und räumlich dargestellt werden; eine wichtige Vorbedingung für die gezielte Entwicklung von neuen Wirkstoffen. Es ist daher nicht verwunderlich, dass ein großer Teil der Autoren dieses Buches bei führenden Pharmaunternehmen tätig ist. Die theoretischen Grundlagen der NMR von Biomolekülen werden dargestellt, und die Anwendung der Kernresonanz in der Strukturaufklärung von Proteinen und Nucleinsäuren demonstriert. Neueste Techniken zur Charakterisierung von Wirkstoff-Rezeptor-Komplexen werden vorgestellt und mit vielen Fallstudien aus der Pharmaforschung untermauert. Mit einer g elungenen Kombination aus Grundlagenwissen und Anwendungsstrategien, inklusive vieler Beispiele aus der Praxis, ist dieses Werk für den NMR-Spektroskopiker wie für den Pharmaforscher ein unentbehrlicher Leitfaden für das aufstrebende Gebiet der BioNMR in der Arzneistoffentwicklung. The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies. With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers. 480 pp. Deutsch. Bookseller Inventory # 9783527304653

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Book Description Wiley VCH Verlag Gmbh Nov 2002, 2002. Buch. Book Condition: Neu. 240x170x380 mm. Neuware - Durch die großen Fortschritte in der Untersuchung von Biomolekülen durch NMR in den letzten Jahren steht mit der NMR-Spektroskopie ein universell einsetzbares Werkzeug zur Untersuchung der Bindung eines Wirkstoffs an sein Zielprotein zur Verfügung, von dessen Einsatz insbesondere die Arzneistoffentwicklung profitiert. Diese Wechselwirkung kann heute mittels NMR in unübertroffener Genauigkeit untersucht und räumlich dargestellt werden; eine wichtige Vorbedingung für die gezielte Entwicklung von neuen Wirkstoffen. Es ist daher nicht verwunderlich, dass ein großer Teil der Autoren dieses Buches bei führenden Pharmaunternehmen tätig ist. Die theoretischen Grundlagen der NMR von Biomolekülen werden dargestellt, und die Anwendung der Kernresonanz in der Strukturaufklärung von Proteinen und Nucleinsäuren demonstriert. Neueste Techniken zur Charakterisierung von Wirkstoff-Rezeptor-Komplexen werden vorgestellt und mit vielen Fallstudien aus der Pharmaforschung untermauert. Mit einer g elungenen Kombination aus Grundlagenwissen und Anwendungsstrategien, inklusive vieler Beispiele aus der Praxis, ist dieses Werk für den NMR-Spektroskopiker wie für den Pharmaforscher ein unentbehrlicher Leitfaden für das aufstrebende Gebiet der BioNMR in der Arzneistoffentwicklung. The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies. With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers. 480 pp. Deutsch. Bookseller Inventory # 9783527304653

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Book Description Wiley VCH Verlag Gmbh Nov 2002, 2002. Buch. Book Condition: Neu. 240x170x380 mm. Neuware - Der kürzlich an Kurt Wüthrich verliehene Nobelpreis für die Methode der BioNMR trägt den großen Fortschritten in der Untersuchung von Biomolekülen durch NMR Rechnung. Herausgegeben von einem ehemaligen Mitarbeiter Wüthrichs, präsentiert dieses Buch die theoretischen Grundlagen zur BioNMR neben deren Einsatzmöglichkeiten zur Strukturaufklärung von Proteinen und Nucleinsäuren. Mit der BioNMR steht nicht zuletzt ein universell einsetzbares Werkzeug zur Untersuchung der Bindung eines Wirkstoffs an sein Zielprotein zur Verfügung, von dessen Einsatz insbesondere die Arzneistoffentwicklung profitiert. Diese Wechselwirkung kann heute mittels NMR in unübertroffener Genauigkeit untersucht und räumlich dargestellt werden; eine wichtige Vorbedingung für die gezielte Entwicklung von neuen Wirkstoffen. Neueste Techniken zur Charakterisierung von Wirkstoff-Rezeptor-Komplexen werden vorgestellt und mit vielen Fallstudien aus der Pharmaforschung untermauert. 480 pp. Deutsch. Bookseller Inventory # 9783527304653

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