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Apoptose no carcinoma colo-retal: IAPs e SMAC: Carcinoma Colo-retal: relao dos inibidores da apoptose IAPs e seu antagonista Smac, ndice apopttico e sobrevida (Portuguese Edition)

Flávio de Oliveira Lima

ISBN 10: 6202406607 / ISBN 13: 9786202406604
Published by Novas Edições Acadêmicas, 2017
Condition: Good Soft cover
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Bibliographic Details

Title: Apoptose no carcinoma colo-retal: IAPs e ...

Publisher: Novas Edições Acadêmicas

Publication Date: 2017

Binding: Paperback

Book Condition: Good

About this title


Objetivos: Avaliar a imuno-expresso de Survivina, XIAP, cIAP-1, cIAP-2 e SMAC/DIABLO em tecido tumoral e mucosa no tumoral adjacente ao tumor de pacientes com cncer colo-retal, no submetidos radio ou quimioterapia. Correlacionar os resultados com o ndice Apopttico, Proliferao Celular e imuno-expresso da protena p53 nestes mesmos tecidos, e com o prognstico dos pacientes. Mtodo: Foi confeccionado um bloco de parafina de TMA com tecido de cncer colo-retal e da mucosa adjacente de 130 pacientes operados no Hospital So Paulo da EPM/UNIFESP, de 2002 a 2005, no submetidos a radio ou quimioterapia. Cortes de 4 m do bloco de TMA foram submetidos reao imuno-histoqumica para survivina, XIAP, cIAP-1, cIAP-2 e SMAC. As lminas foram lidas independentemente por trs patologistas experientes, sendo obtidos escores de intensidade de imunoexpresso. Esses escores foram correlacionados entre si e com o IA obtido com o uso dos anticorpos anti-caspase 3 clivada e M30 (citoqueratina 18 clivada), ndice de proliferao celular, imunoexpresso da protena p53 e dados de sobrevida dos pacientes.

About the Author:

Possui graduao em Medicina pela Faculdade de Cincias Mdicas da Santa Casa de So Paulo (1987), residncia mdica em Anatomia Patolgica pela Escola Paulista de Medicina - UNIFESP/Faculdade de Medicina de Botucatu - UNESP(1990/1991), mestrado/doutorado em Anatomia Patolgica pela UNIFESP. professor assistente de Patologia da FMB-UNESP.

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