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Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing

Charles E. Samuel

Published by Springer-Verlag Gmbh Nov 2011, 2011
ISBN 10: 3642228003 / ISBN 13: 9783642228001
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Title: Adenosine Deaminases Acting on RNA (ADARs) ...

Publisher: Springer-Verlag Gmbh Nov 2011

Publication Date: 2011

Binding: Buch

Book Condition: Neu

Description:

Neuware - 'The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.' 238 pp. Englisch. Bookseller Inventory # 9783642228001

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Synopsis: "The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they  act to affect gene expression and  function.  It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property.  Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.  Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins."

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