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Actin-based Motility

Marie-France Carlier

Published by Springer-Verlag Gmbh Nov 2010, 2010
ISBN 10: 9048193001 / ISBN 13: 9789048193004
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Title: Actin-based Motility

Publisher: Springer-Verlag Gmbh Nov 2010

Publication Date: 2010

Binding: Buch

Book Condition: Neu


Neuware - Since the discovery of actin by Straub in the 1950's and the pioneering work of Oosawa on actin self-assembly in helical laments in the 1960's, many books and conference proceedings have been published. As one of the most essential p- teins in life, essential for movement in organisms rangingfrom bacteria to higher eukaryotes, it is no surprise that actin has fascinated generations of scientists from many different elds. Actin can be considered as a 'living treasure' of biology; the kinetics and thermodynamics of self-assembly, the dissipative nature of actin po- merization, the molecular interactions of monomeric and polymerized actin with regulators, the mechanical properties of actin gels, and more recently the force p- ducing motile and morphogenetic processes organized by the actin nanomachine in response to signaling, are all milestones in actin research. Discoveries that directly derive from and provide deeper insight into the fundamental properties of actin are constantly being made, making actin an ever appealing research molecule. At the same time, the explosion in new technologies and techniques in biological sciences has served to attract researchers from an expanding number of disciplines, to study actin. This book presents the latest developments of these new multiscale approaches of force and movement powered by self-assembly processes, with the hope to opening our perspectives on the many areas of actin-based motility research. 435 pp. Englisch. Bookseller Inventory # 9789048193004

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Synopsis: This book presents the cellular, molecular and physical aspects of production of force and movement by self-assembly of actin, one of the most abundant protein in cells, into cytoskeletal filaments. « Actin-based motile processes » are responsible for a very large variety of motile activities of cells in their physiological and pathological states, covering chemotactic locomotion, embryonic and metastatic cell migration, wound healing, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic activities, as well as morphogenetic processes like axis patterning in early embryo, axonal growth in brain development, immune response and synaptic plasticity processes at the origin of learning and memory. The different chapters of the book describe how the multidisciplinary multiscale approaches taken in the recent years have explored the molecular and physical mechanisms at the origin of force and movement produced by actin self-assembly. The chosen topics show how advances have been made in the field of cell motility due to progress in live cell imaging, light microscopy, improved resolution in the structure of large protein assemblies, biochemical analysis and mathematical modeling of actin assembly dynamics and development of nanotechnologies allowing to measure forces in the range of pico- to nano-newton produced by actin assemblies.

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