This book presents, in a user-friendly form, a guide to the understanding of acid-base physiology and clinical disorders of acid-base balance. The unique feature of this book is that instead of the traditional description of proton and bicarbonate behavior as vectors, this book relies on physical metaphors_ exchangers, pumps and ion channels _ in much the same way as the heart is understood as a pump and the lungs as a bellows. This presentation is strongly supported by the present understanding of the shape and function of these transport proteins.

Synopsis:

Acid-base metabolism is of fundamental clinical relevance and is one of the areas of biochemistry and physiology least well understood by medical students and physicians. The past ten years have seen tremendous advances in the molecular understanding of ion transport and the physiological basis for acid-base disorders. This book takes an easy and informal approach to draw the readers, primarily residents and medical students, to a real understanding of the intricacies of the biochemistry and physiology of acid-base disorders.

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