Nifidipine Matrix Tablet: Formulation Development and Evaluation - Softcover

Akhter, Dewan Taslima; Uddin, Riaz; Rana, Md. Sohel

Softcover

ISBN 10: 3846589918 ISBN 13: 9783846589915

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

The purpose of the present work was to design & evaluate sustained release tablets of Nifedipine, employing hydrophilic polymer to improve dissolution rates of the drug. METHOCEL K15MCR & METHOCEL K100LVCR were used in tablets prepared by direct compression. The formulated tablets were physicochemically characterized & results were found in acceptable limits. Poor aqueous solubility of Nifedipine leads to variable dissolution rates. The main effect & interaction terms were quantitatively evaluated using mathematical models. Dissolution data were fitted to zero order, first order, Higuchi's, Korsmeyer-Peppas & Hixson-Crowell release kinetics to evaluate kinetic data. The drug release data fit well to the Higuchi expression, but a close relationship was also noted with zero order kinetics. Korsmeyer’s plot indicated that the drug release mechanism from the matrix tablet was to be found Fickian mechanism. Regulated drug release study indicate that the matrix tablets of Nifedipine prepared using above polymers can successfully be employed as twice-a-day oral controlled release dosage form.

About this title

About the Author

Dewan Taslima Akhter has obtained her B.Pharm (Hons) & MS in Pharmaceutical Science from Jahangirnagar University and working as Lecturer in Dept. of Pharmacy, Stamford University Bangladesh (SUB). Riaz Uddin is graduated from SUB and is working as Lecturer in the same. Dr. Md. Sohel Rana is Professor in Dept. of Pharmacy, Jahangirnagar University.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3846589918
• ISBN 13: 9783846589915
• Binding: Paperback
• Number of pages: 148