Robotics and Geometric Mechanics Approach to Structural Biology: For Modeling Protein Folding and Inflection Point Detection - Softcover

Sawlekar, Rucha; Kazi, Faruk; Singh, Navdeep M.

Softcover

ISBN 10: 3659372676 ISBN 13: 9783659372674

Publisher: LAP LAMBERT Academic Publishing, 2013

Synopsis

The voluminous application area of Dynamics and Control as well as Systems Biology, is an upcoming and challenging research area assiduously followed by control research community. This book focuses on Protein structure prediction, Missing loop problem and Optimal alignment of two protein structures. The Missing loop problem is treated by Robotics based Inverse Kinematics (IK) method to generate the possible candidates’ ensemble for protein loop completion. Then structure prediction of proteins (namely 1YRF and 1VII) is achieved by differential geometric approach and Frenet-Quaternion frame compared with the results by nonlinear Schrödinger equation; considering the structural similarity between a protein chain and a robotic arm. The results clearly show the location of inflection points that distinctly determine helix-loop-helix structure of the protein under study. Also, Quaternion based optimal alignment of two protein structures is performed and compared with the results by Kabsch method.

About this title

About the Author

Rucha Sawlekar received her Masters’ degree in Electrical Engineering with specialization in Control Systems from VJTI, Mumbai University in 2012 and worked with the same institute as an Assistant Professor. Her research interests are in Dynamics and Control, Robotics, Protein Dynamics and Systems Biology.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2013
• ISBN 10: 3659372676
• ISBN 13: 9783659372674
• Binding: Paperback
• Language: English
• Number of pages: 96