Towards Offline PET Monitoring at a Cyclotron-Based Proton Therapy Facility: Experiments and Monte Carlo Simulations (BestMasters) - Softcover

Würl, Matthias

Softcover

ISBN 10: 3658131675 ISBN 13: 9783658131678

Publisher: Springer Spektrum, 2016

Synopsis

Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.

About this title

About the Author

Matthias Würl wrote his Master’s Thesis at the chair of Medical Physics at the Ludwig-Maximilians University Munich. He is now a PhD student at the same department, working on transmission imaging with laser-accelerated ions.

From the Back Cover

Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.

Contents

• Monte Carlo Modeling of a Clinical Proton Beam
  
• Low-Dose Envelope and Field Size Factor
  
• PET Activation Studies
  

Target Groups

• Researchers and students in the field of medical physics with focus on particle therapy
  
• Medical physicists at proton therapy facilities
  

The Author

Matthias Würl wrote his Master’s Thesis at the chair of Medical Physics at the Ludwig-Maximilians University Munich. He is now a PhD student at the same department, working on transmission imaging with laser-accelerated ions.

Edition details

• Publisher: Springer Spektrum
• Publication date: 2016
• Language: English
• ISBN 10: 3658131675
• ISBN 13: 9783658131678
• Binding: Paperback
• Edition number: 1
• Number of pages: 101