Search for Breast Cancer Susceptibility Genes: The Growth Hormone-1 / Insulin-like Growth Factor-1 Pathway and its Relationship to Breast Cancer

 
9783639022070: Search for Breast Cancer Susceptibility Genes: The Growth Hormone-1 / Insulin-like Growth Factor-1 Pathway and its Relationship to Breast Cancer
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Breast Cancer is the most common cancer in Western women and represents 28% of female cancer deaths. During the last decades, research has revealed cancer as a complex heterogeneous disease triggered by dynamic changes in the genome. The work in this dissertation summarizes the investigation of polymorphisms in the GH1/IGF-1 axis in relation to breast cancer risk by means of the planning and conducting of case-control studies. Many findings were novel and they reflected the complexity of the gene regulation along the GH1/IGF-1 pathway. In summary, the studied polymorphisms were mainly associated with a decreased breast cancer risk. This lead to the suggestion that genetic variants in the GH1/ IGF-1 axis do not increase the mitogenic and antiproliferative features of the pathway, but rather protect the cells from proliferation. The study contributes to the world-wide effort of identification of low-penetrance genetic variants, which may be useful tools for prevention, prognosis and planning of individual therapy.

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About the Author:

Kerstin Wagner studied Biotechnology at the University of Applied Science in Mannheim, Germany and graduated in 2003. She worked as a PhD student at the German Cancer Research Center (DKFZ) in Heidelberg and completed her PhD (Dr.sc.hum) in June 2006. Since 2007, she is working in Clinical Research with focus on Phase II/III trials.

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Book Description Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | The Growth Hormone-1 / Insulin-like Growth Factor-1 Pathway and its Relationship to Breast Cancer | Breast Cancer is the most common cancer in Westernwomen and represents 28% of female cancer deaths.During the last decades, research has revealed canceras a complex heterogeneous disease triggered bydynamic changes in the genome. The work in this dissertation summarizes theinvestigation of polymorphisms in the GH1/IGF-1 axisin relation to breast cancer risk by means of theplanning and conducting of case-control studies. Manyfindings were novel and they reflected the complexityof the gene regulation along the GH1/IGF-1 pathway.In summary, the studied polymorphisms were mainlyassociated with a decreased breast cancer risk. Thislead to the suggestion that genetic variants in theGH1/ IGF-1 axis do not increase the mitogenic andantiproliferative features of the pathway, but ratherprotect the cells from proliferation. The studycontributes to the world-wide effort ofidentification of low-penetrance genetic variants,which may be useful tools for prevention, prognosisand planning of individual therapy. | Format: Paperback | Language/Sprache: english | 132 pp. Seller Inventory # K9783639022070

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Book Description VDM Verlag, Germany, 2008. Paperback. Condition: New. Language: English . Brand New Book ***** Print on Demand *****.Breast Cancer is the most common cancer in Western women and represents 28 of female cancer deaths. During the last decades, research has revealed cancer as a complex heterogeneous disease triggered by dynamic changes in the genome. The work in this dissertation summarizes the investigation of polymorphisms in the GH1/IGF-1 axis in relation to breast cancer risk by means of the planning and conducting of case-control studies. Many findings were novel and they reflected the complexity of the gene regulation along the GH1/IGF-1 pathway. In summary, the studied polymorphisms were mainly associated with a decreased breast cancer risk. This lead to the suggestion that genetic variants in the GH1/ IGF-1 axis do not increase the mitogenic and antiproliferative features of the pathway, but rather protect the cells from proliferation. The study contributes to the world-wide effort of identification of low-penetrance genetic variants, which may be useful tools for prevention, prognosis and planning of individual therapy. Seller Inventory # AAV9783639022070

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