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Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy: v. 33 (Ernst Schering Foundation Symposium Proceedings) - Hardcover

 
9783540677017: Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy: v. 33 (Ernst Schering Foundation Symposium Proceedings)
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The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop­ ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop. Indeed, at first glance the recovery of stem cells from cord blood has to be seen as separate from the attempts to achieve effective in utero therapy by stem cell trans­ plantation, because the first issue deals with an innovative stem cell source as an alternative to bone marrow, which is already spreading rapidly in medical practice, whereas the second topic is still strictly ex­ perimental and only investigated in medical centers with the appropri­ ate background. It is, however, not only justified, but helpful to com­ bine the two topics in one workshop and consequently to cover them in the same volume of the Ernst Schering Research Foundation Work­ shop series, because they are intimately related and both based on the new insights into the biology of stem cells. Professor Werner Arber, the Nobel Laureate from the University of Basel, pointed out in his In- Professor Dr. W. Holzgreve VI Preface The participants of the workshop troductory Lecture that our understanding of hematopoietic stem cells as descendents of totipotent cells and our current approaches to using them in post-and prenatal therapy have been furthered significantly by genetic engineering technologies which are "artificial contributions to the process of biologic evolution".

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This text deals with two different developments with haematopoietic stem cells. The first is their retrieval from cord blood as an alternative to bone marrow. Since this approach was first suggested in 1990, there has been worldwide activity to establish cord blood banks, and more than 10,000 samples have been entered and 1000 transplanted in one centre alone. The second application of haematopoietic stem cells is therapy in utero, for example of inborn errors of metabolism. The first successful treatment of effective severe combined immunodeficiency in utero have been reported, though many problems remain to be solved.

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  • PublisherSpringer
  • Publication date2000
  • ISBN 10 3540677011
  • ISBN 13 9783540677017
  • BindingHardcover
  • Number of pages229
  • EditorHolzgreve W., Lessl M.
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