G Proteins, Receptors, and Disease (Contemporary Endocrinology)

4 avg rating
( 1 ratings by Goodreads )
 
9781461272908: G Proteins, Receptors, and Disease (Contemporary Endocrinology)
View all copies of this ISBN edition:
 
 

"Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders. This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins.

"synopsis" may belong to another edition of this title.

Review:

Winner of one of the Best 1998 Health Sciences Books Awards!
"The book meets the stated objective. . .[of] providing the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related diseases. . .Each chapter is truly a state-of-the-art description."4 Stars!-Doody's Health Sciences Book Review Journal

"...attractive in its presentation and well illustrated with good quality photographs. . .bibliographies are current and extensive. . .a pleasure to read. . .would complement every medical library and should be highly recommended to clinical and basic scientists."-European Journal of Endocrinology

"G Proteins, Receptors, and Disease is a volume worthy of a place on the bookshelf of anyone with a current interest in endocrine disease and GPCR-targeted approaches to therapeutics....it is refreshing to find a book that communicates just how much genomics-based research can accelerate understanding, not just of a discrete area of science, but of human disease."- Nature Medicine

From the Back Cover:

More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, outlines possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Diagnostic and therapeutic implications are also discussed when relevant.

In its unique blend of cutting-edge basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway, as well as into the molecular basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.

"About this title" may belong to another edition of this title.

Other Popular Editions of the Same Title

9780896034303: G Proteins, Receptors and Disease (Contemporary Endocrinology)

Featured Edition

ISBN 10:  0896034305 ISBN 13:  9780896034303
Publisher: Humana Press, 1998
Hardcover

Top Search Results from the AbeBooks Marketplace

1.

Published by Springer-Verlag New York Inc., United States (2012)
ISBN 10: 1461272904 ISBN 13: 9781461272908
New Paperback Quantity Available: 10
Seller:
The Book Depository
(London, United Kingdom)

Book Description Springer-Verlag New York Inc., United States, 2012. Paperback. Condition: New. Language: English. Brand new Book. "Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders.This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins. Softcover reprint of the original 1st ed. 1998. Seller Inventory # AAV9781461272908

More information about this seller | Contact this seller

Buy New
77.79
Convert currency

Add to Basket

Shipping: FREE
Within United Kingdom
Destination, rates & speeds

2.

Published by Springer-Verlag New York Inc., United States (2012)
ISBN 10: 1461272904 ISBN 13: 9781461272908
New Paperback Quantity Available: 10
Seller:
Book Depository hard to find
(London, United Kingdom)

Book Description Springer-Verlag New York Inc., United States, 2012. Paperback. Condition: New. Language: English. Brand new Book. "Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders.This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins. Softcover reprint of the original 1st ed. 1998. Seller Inventory # LIE9781461272908

More information about this seller | Contact this seller

Buy New
77.79
Convert currency

Add to Basket

Shipping: FREE
Within United Kingdom
Destination, rates & speeds

3.

Spiegel, Allen M.
Published by Humana Press (2017)
ISBN 10: 1461272904 ISBN 13: 9781461272908
New Paperback Quantity Available: 10
Print on Demand
Seller:
Ria Christie Collections
(Uxbridge, United Kingdom)

Book Description Humana Press, 2017. Paperback. Condition: New. PRINT ON DEMAND Book; New; Publication Year 2017; Not Signed; Fast Shipping from the UK. No. book. Seller Inventory # ria9781461272908_lsuk

More information about this seller | Contact this seller

Buy New
77.80
Convert currency

Add to Basket

Shipping: FREE
Within United Kingdom
Destination, rates & speeds

4.

Allen M. Spiegel
Published by Humana Press (2012)
ISBN 10: 1461272904 ISBN 13: 9781461272908
New Quantity Available: > 20
Print on Demand
Seller:
Books2Anywhere
(Fairford, GLOS, United Kingdom)

Book Description Humana Press, 2012. PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # IQ-9781461272908

More information about this seller | Contact this seller

Buy New
82.76
Convert currency

Add to Basket

Shipping: FREE
Within United Kingdom
Destination, rates & speeds

5.

Published by Springer-Verlag New York Inc., United States (2012)
ISBN 10: 1461272904 ISBN 13: 9781461272908
New Paperback Quantity Available: 10
Seller:
Book Depository International
(London, United Kingdom)

Book Description Springer-Verlag New York Inc., United States, 2012. Paperback. Condition: New. Language: English. Brand new Book. "Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders.This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins. Softcover reprint of the original 1st ed. 1998. Seller Inventory # AAV9781461272908

More information about this seller | Contact this seller

Buy New
85.53
Convert currency

Add to Basket

Shipping: FREE
Within United Kingdom
Destination, rates & speeds

6.

Allen M. Spiegel
Published by Humana Press (2012)
ISBN 10: 1461272904 ISBN 13: 9781461272908
New Quantity Available: > 20
Print on Demand
Seller:
Paperbackshop-US
(Wood Dale, IL, U.S.A.)

Book Description Humana Press, 2012. PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # IQ-9781461272908

More information about this seller | Contact this seller

Buy New
85.55
Convert currency

Add to Basket

Shipping: 0.80
From U.S.A. to United Kingdom
Destination, rates & speeds

7.

Published by Humana Press (2012)
ISBN 10: 1461272904 ISBN 13: 9781461272908
New Paperback Quantity Available: 2
Seller:
Revaluation Books
(Exeter, United Kingdom)

Book Description Humana Press, 2012. Paperback. Condition: Brand New. reprint edition. 336 pages. In Stock. Seller Inventory # x-1461272904

More information about this seller | Contact this seller

Buy New
117.42
Convert currency

Add to Basket

Shipping: 15
Within United Kingdom
Destination, rates & speeds