Cell Transformation Systems Relevant to Radiation Induced Cancer in Man, Proceedings of a Workshop jointly organised by the Nuclear Energy Board of ... held in Du (Eur (Series), 12248.) - Hardcover

Ireland Nuclear Energy Board; United States Department Of Energy; Commission Of The European Communities

Hardcover

ISBN 10: 0852740840 ISBN 13: 9780852740842

Publisher: CRC Press, 1989

Synopsis

The transformation of mammalian cells in vitro provides quantitative and qualitative information on the processes by which physical and chemical agents induce malignancy. Recently, there has been considerable progress on the developmnent of new cell transformation systems and the role of oncogenes in cell transformation. An International Workshop held during April 1989 in Dublin encouraged collaborative interactions between the scientists working in this field and provided a forum for critical review of current research results. Cell Transformation and Radiation-induced Cancer is a record of the papers presented at the Workshop. It includes work which focuses on the potential of emerging human cell transformation systems and their relevance to radiation carcinogenesis, and on the role and interplay of oncogenes, retroviruses and radiation in cell transformation. Particular emphasis is placed on the influence of such variables as radiation quality, dose and dose rate, promoters and suppressors and cell types on in vitro cell transformation. Also considered are the implications of the results from cell transformation studies for radiation-induced cancer in man and for radiological protection. This book will be of interest to molecular biologists, medical physicists and cancer specialists who require a comprehensive account of the latest work on cell transformation and radiation-induced cancer.

About this title

Synopsis

The transformation of mammalian cells "in vitro" provides quantitative and qualitative information on the processes by which physical and chemical agents induce malignancy. Radiation induced cancer is a major concern in radiological protection and cell transformation systems offer a complementary research pathway to epidemiological studies of exposed human populations and to animal experiments. Results from cell transformation research can provide information about the shape of dose-effect relationships, the role of dose rate and radiation quality, and the modifying effect of agents present during and after radiation exposure. Data can be obtained on initiation and promotion in the cancer proces. In 1985 a workshop was organised on `Cell Transformation in Radiobiology' which reviewed the then existing data on radiation-induced cell transformation but the proceedings were, unfortunately, never published. Since then considerable progress has been made especially on the development of new cell transformation systems more relevant to human cancer and on the role of genetic factors, such as oncogenes and surpressor or anti-onco genes in cancer.

In addition much more information is available on the effect of dose, dose rate, radiation quality and modifying factors on the frequency of transformation in the more `classical' cell transformation systems. The Radiation Protection Programme of DGXII of the Commission of the European Communities, the Office for Health and Environmental Research of the United States Department of Energy and the Nuclear Energy Board of Ireland organised a workshop on `Cell Transformation Systems Relevant to Radiation-Induced Cancer in Man' in Dublin from 4-7 April 1989 to provide a review of the current research and to encourage collaborative interactions between scientists working in the field. This book presents the proceedings of that workshop which should be of interest to cell biologists, oncologists, radiobiologists, biophysicists, cytologists, chemical toxicologists as well as others concerned with the scientific background to radiation-induced cancer.

Edition details

• Publisher: CRC Press
• Publication date: 1989
• Language: English
• ISBN 10: 0852740840
• ISBN 13: 9780852740842
• Binding: Hardcover
• Edition number: 1
• Number of pages: 428
• Editor: Chadwick K. H., Seymour C., Barnhart Benjamin J.