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As a teenager, Pierre Tardivel discovers that he has a 50 per cent chance of developing the hereditary Huntington's disease. The knowledge drives him to become a scientist working on the Human Genome Project at Berkley University, where he falls in love with Molly, a psychologist with the genetic "frameshift" for telepathy. A series of murders are traced to local neo-Nazis, someone is conducting an illegal experiment with Neanderthal DNA, and Department of Justice Agent Avi Meyer is hunting Ivan Marchenko, the concentration camp guard known as Ivan the Terrible, The Butcher of Treblinka.
What makes Frameshift remarkable is the sympathetic and realistic portrayal of a progressively disabled hero, together with the interweaving into the story of the hunt for a real Nazi war criminal. Here Sawyer skilfully draws on the scandalous persecution of John Demjanjuk, a man mistakenly tried as Marchenko in the 1980's, a case documented in Yoram Sheftel's powerful Show Trial.
Robert J. Sawyer has woven a labyrinthine novel encompassing sufficient themes and plots for a handful of ordinary thrillers. He offers complex and imaginative scientific speculation, a thoughtful examination of the ethical implications of genetic testing, a slow-burning but dramatic thriller with a blockbuster climax, and a touching love story with a genuinely moving ending. Frameshift is a griping, and ultimately inspiring novel.--Gary S. Dalkin
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