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The challenge of scaling the highest mountain, exploring the deepest ocean, crossing the hottest desert, or swimming in near-freezing water is irresistible to many people. Life at the Extremes is an engrossing exploration of what happens to our bodies in these seemingly uninhabitable environments. Frances Ashcroft weaves stories of extraordinary feats of endurance with historical material and the latest scientific findings as she investigates the limits of human survival and the remarkable adaptations that enable us to withstand extreme conditions.

What causes mountain sickness? How is it possible to reach the top of Everest without supplementary oxygen, when passengers in an airplane that depressurized at the same altitude would lose consciousness in seconds? Why do divers get the bends but sperm whales do not? How long you can survive immersion in freezing water? Why don't penguins get frostbite? Will men always be faster runners than women? How far into deep space can a body travel?

As she considers these questions, Ashcroft introduces a cast of extraordinary scientific personalities—inventors and explorers who have charted the limits of human survival. She describes many intriguing experiments and shows how scientific knowledge has enabled us to venture toward and beyond ever greater limits. Life at the Extremes also considers what happens when athletes push their bodies to the edge, and tells of the remarkable adaptations that enable some organisms to live in boiling water, in highly acidic lakes, or deep in the middle of rocks.

Anyone who flies in an airplane, sails the high seas, goes skiing or walking in the mountains, or simply weathers subzero winters or sweltering summers will be captivated by this book. Full of scientific information, beautifully written, and packed with many fascinating digressions, Life at the Extremes lures us to the very edge of human survival.

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Review:
In Life at the Extremes Frances Ashcroft, Professor of Physiology at Oxford University, investigates the related questions: how much can the human body endure? What can it survive, what causes it to fail? Why can some creatures tolerate conditions that would kill others? The extremes in question, to which bodies are periodically subjected, either voluntarily or not, include the limits of endurable temperature and pressure; physical constraints on speed; the weightlessness, vacuum and utter cold of space; and a number of environments that, for various reasons, are so unpleasant as to limit drastically the options of life-forms that attempt to inhabit them. By its nature, such a subject does not lend itself to continuous narrative, and Life at the Extremes may be best regarded as a kind of anthology into which one can dip to pull out examples, cheerful or gruesome, of what can happen to living tissue at the extremes. Here is Mr Blagden, accompanied by some eggs, a raw steak and a dog, entering a room heated to 105 degrees C, in the late 18th century. Fifteen minutes later the steak and eggs were cooked but Mr Blagden and the dog were not. A clear and absorbing explanation of mammalian heat regulation follows. Here are dreadful pictures of frost-bitten extremities; Sir Roger Bannister breaking the four-minute mile; a frog frozen solid in a block of ice but still alive and well; divers and the bends; astronauts and the redistribution of bodily fluids in weightlessness; flamingos enduring their caustic soda lakes; the physiology of the chilblain. Frances Ashcroft writes warmly and with wit: her many illustrative anecdotes are well chosen and provoke much thought about how life copes with, and adapts to, the physical circumstances it finds itself in. --Robin Davidson
Review:
"In seven excellent chapters, Ashcroft describes life at extreme elevation, under the pressure of ocean depths, at high temperature, at low temperature, at high (but self-propelled) speed, in space, and at the very limits of physical conditions for any kind of life."--"Choice

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